A Review on Mouth Dissolving Film

  • Rajat Pawar Acropolis Institute of pharmaceutical Education and Research, Indore, M.P., India
  • Ravi Sharma Acropolis Institute of pharmaceutical Education and Research, Indore, M.P., India
  • Pravin Sharma Acropolis Institute of pharmaceutical Education and Research, Indore, M.P., India
  • G.N. Darwhekar Acropolis Institute of pharmaceutical Education and Research, Indore, M.P., India

Abstract

Mouth dissolving film is the most advanced oral solid dosage form due to its flexibility and comfort in use. Mouth dissolving films are oral solid dosage form that disintegrate and dissolve within a minute when placed in mouth without taking water or chewing. This dosage form allows the medication to bypass the first pass metabolism so bioavailability of medication may be improved .Mouth dissolving film has potential to improve onset of action lower the dosing and eliminate the fear of chocking. Formulation of mouth dissolving films involves both the visual and performance characteristics as plasticized hydrocolloids, API taste masking agents are being laminated by solvent casting and semisolid casting method. Solvent casting method being the most preferred method over other methods because it offers great uniformity of thickness and films prepared having fine glossy look and better physical properties. Mouth dissolving films are evaluated for its various parameters like thickness, physical property like folding endurance, disintegration and dissolution time. This review gives an idea about formulation techniques, evaluation parameters, overview on packaging and some available marketed products of mouth dissolving films.


Keywords: Mouth dissolving film, solvent casting, fast disintegration

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References

1.Arya, A., Chandra, A., Sharma, V., Pathak, K., 2010. Fast dissolving oral films: an innovative drug delivery system and dosage form. Int. J. Chem. Tech. Res. 2, 576–583.
2. Bai, G., Armenante, P.M., Plank, R.V., Gentzler, M., Ford, K., Harmon, P., 2007. Hydrodynamic investigation of USP dissolution test apparatus II. J. Pharm. Sci. 96, 2327–2349.
3. Bala, R., Pawar, P., Khanna, S., Arora, S., 2013. Orally dissolving strips: A new approach to oral drug delivery system. Int. J. Pharm. Investig. 3, 67–73.
4. Chaudhary, H., Gauri, S., Rathee, P., Kumar, V., 2013. Development and optimization of fast dissolving oro-dispersible films of granisetron HCl using Box-Behnken statistical design. Bullet. Faculty Pharm. 51, 193–201.
5. Chauhan, I., Yasir, M., Nagar, P., 2012. Insights into polymers: film formers in mouth dissolving films. Drug Invent. Today 3, 56–73.
6.Desu, P.K., Brahmaiah, B., Nagalakshmi, A., Neelima, K., Nama, S., Baburao, C., 2013. An overview on rapid dissolving films. Asian J. Pharm. Res. 3, 15–23.
7. Dinge, A., Nagarsenker, M., 2008. Formulation and evaluation of fast dissolving films for delivery of triclosan to the oral cavity. AAPS Pharm. Sci. Tech. 9, 349–356.
8. Elmeshad1, A.N., Hagrasy, A.S.E., 2011. Characterization and optimization of orodispersible mosapride film formulation. AAPS Pharm. Sci. Tech. 12, 1384–1392.
9.Goel H, Rai P, Rana V, Tiwary A. Orally Disintegrating Systems: Innovations in Formulation and Technology. Recent Patents on Drug Delivery & Formulation. 2008; 2(3):258-274.
10. Prabhu SC, Parsekar SD, Shetty A, Monteiro SS, Azharuddin M, Shabaraya AR. A Review on Fast Dissolving Sublingual Films for Systemic Drug Delivery. Int J Pharm Chem Sci. 2014; 3(2):501-11.
11.Russo E, Selmin F, Baldassari S, Gennari C, Caviglioli G, Cilurzo F et al. A focus on mucoadhesive polymers and their application in buccal dosage forms. Journal of Drug Delivery Science and Technology. 2015;32:113-125.
12. Wening K Breitkreutz J. Oral drug delivery in personalized medicine: Unmet needs and novel approaches. Int J Pharm. 2011;404(1-2):1-9.
13. Hariharan M, Bogue A. Orally dissolving film strips (ODFS): the final evolution of orally dissolving dosage forms. Drug Deliv Technol. 2009 Feb;9(2):24-9.
14. Sakellariou P, Rowe R, White E. An evaluation of the interaction and plasticizing efficiency of the polyethylene glycols in ethyl cellulose and hydroxypropyl methylcellulose films using the torsional braid pendulum. IntJ Pharm. 1986; 31(1-2):55-64.
15. Patil PC, Shrivastava SK, Vaidehi S, Ashwini P. Oral Fast Dissolving drug delivery system: A modern approach for patient compliance. Int J Drug Regulatory Affairs. 2014 Jun 1; 2(2):49-60.
16. Rekha MR, Sharma CP. Pullulan as a promising biomaterial for biomedical applications: a perspective. Trends BiomaterArtif Organs. 2007; 20(2):116-21.
17. U.S. Congress, Office of Technology Assessment, Biopolymers: Making Materials Nature’s Way-Background Paper, OTA-BP-E-102 (Washington, DC: U.S. Government Printing Office, 1993).
18. Saini S, Rana AC, Gupta S. Optimization of formulation of fast dissolving films made ofpullulan polymer. Int J Pharm Sci Rev Res. 2011;9(1):127-31.
19.laudia, A. R. B., Bello-Perez, L. A.Gacia, M. A.; Martino, M. N.; Solorza-Feria, J.; Zaritzky, N. E. Carbohyd. Polym. 2005; 60: 235-244.
20. Laohakunjit N, Noomhorm A. Effect of plasticizers on mechanical and barrier properties of rice starch film. Starch/Staerke 2004; 56:348–356.
21. Wu Y, Weller C, Hamouz F, Cuppett S, Schnepf M. Moisture Loss and Lipid Oxidation for Precooked Ground-Beef Patties Packaged in Edible Starch-Alginate-Based Composite Films. Journal of Food Science. 2001;66(3):486-493.
22. El-SetouhyDEl-Malak N. Formulation of a Novel Tianeptine Sodium Orodispersible Film. AAPS PharmSciTech. 2010; 11(3):1018-1025.
23. Kunte S, Tandale P. Fast dissolving strips: A novel approach for the delivery of verapamil. J Pharm Bio Sci. 2010;2(4):325-328.
24. Ramani C.C., Puranik P.K., Dorl A.K. Study of diabetic acid as matrix forming material. Int J Pharm. 1996; 137:11-19.
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How to Cite
Pawar, R., Sharma, R., Sharma, P., & Darwhekar, G. (2019). A Review on Mouth Dissolving Film. Journal of Drug Delivery and Therapeutics, 9(6), 206-210. https://doi.org/10.22270/jddt.v9i6.3676