Susceptibility Pattern of Isolated Pathogenic Oral Bacteria to Some Commonly Prescribed Antibiotics in Dental and General Medical Practice
The current global rise in the morbidity and mortality rates of infectious diseases is due in part, to the problem of antimicrobial resistance. The global threat of antimicrobial resistance is also partly a consequence of widespread inappropriate prescription and use of antibiotics, sometimes on empirical basis, without any established antimicrobial susceptibility data-based guidelines on such empirical use. In the present study, we re-examined the susceptibility pattern of organisms isolated from active carious lesions to some commonly prescribed antibiotics and suggest a comprehensive data generation and establishment of guidelines based on a holistic assessment of susceptibility pattern of different organisms to the different classes of antibiotics commonly prescribed in various branches of medicine. For instance, our results revealed significant resistance of cariogenic organisms such as Streptococcus mutans and Lactobacillus to Amoxicillin, Gentamicin, Tarivid, Chloramphenicol and Sparfloxacin, with good susceptibility to Ciprofloxacin, Ofloxacin, Pefloxacin and Streptomycin. These findings suggest that the latter group of antibiotics could function better than Amoxicillin in the prophylactic and empirical management of dental caries and other oral infections prior to obtaining antimicrobial susceptibility test results.
Keywords: Antimicrobial, Susceptibility, Empirical, Resistance.
2. Loffler C, Bohmer F, Hornung A, Lang H, Burmeister U, Podbielski A, Wollny A, Gunther K and Altiner A. Dental care Resistance Prevention and Antibiotic Prescribing Modification – The Cluster Randomized Controlled DREAM Trial. Implementation Science, 2014; 9(1):27
3. Balakrishnan M, Simmond RS and Tagg JR. Dental caries is a Preventable Infectious Disease. Aust. Dent. J., 2000; 45(4):235 – 245
4. Sweeney LC, Jayshree D, Chambers AP and Heritage G. Antibiotic Resistance in General Dental Practice – A Cause for Concern? Journal of Antimicrobial Chemotherapy, 2004; 53:567 – 576
5. Onoriode O and Oshomoh EO. Antibacterial Activity of Methanol and Chloroform Extracts of Spilanthes oleracea Plant on Isolated Pathogenic Oral Bacteria. Journal of Applied Sciences and Environmental Management, 2018; 22(2):237 – 245
6. Borna M, Clark NM, Zhanel GG and Lynch JP. Antimicrobial Resistance in Hospital Acquired Gram-Negative Bacterial Infections. Chest, 2015; 147(5):1413 – 1421
7. Manjunath PP, Bhavna S and Sreekanth B. Dental Practitioner’s Knowledge and Practices Regarding Antibiotic Prescription and Development of Resistance: A Cross Sectional Study. J. Indian Assoc. Public Health Dent., 2018; 16(2):144-148
8. Vardhan HT, Lakhshmi NV and Haritha B. Exploring the Pattern of Antibiotic Prescription by Dentists: A Questionnaire-Based Study. J. NTR Univ. Health Sci., 2017; 6:149-153
9. Montero M. Antimicrobial Resistance. What Should Dentists be doing? Int. J. Dent. Sci., 2016; 18:10 – 14
10. Bascones MA, Aguirre-Urizar JM, Bermejo FA, Blanco CA, Gay-Escoda C, Gonzalez-Moles MA et al. Documento de Consenso Sobre et Tratamiento Antimicrobiano de las Infecciones Bacterianas Odontogenicas. Med. Oral Patol. Oral Cir. Bucal, 2004; 9:369 – 376
11. Ozden B, Boucharin A, Tano E, Anderson DI and Elf J. Antibiotics Susceptibility Testing in Less Than 30 Minutes Using Direct Single Cell Imaging. Proc. Natl. Acad. Sci. U.S.A, 2017; 114(34):9170 – 9175
12. Segura JE, Gould K, Hakansen B, Jonasson P, Cotti E, Mazzoni A, Sunay H, Tjaderhane L and Dummer PM. Antibiotics in Endodontics: A Review. International Endodontic Journal, 2016; 50(12):1169 – 1184
13. Rafeal PR, Jose-Vicente B, Jose-Maria SB and Enrique CP. Antibiotic Use in Dental Practice. A Review. Med. Oral Patol. Oral Cir. Bucal, 2007; 12:186 – 192
14. Devi A, Singh V and Bhatt AB. Antibiotic Sensitivity Pattern of Streptococcus against Commercially Available drugs and Comparison with Extract of Punica granatum. International Journal of Pharma and Biosciences, 2011; 2(2):504 – 508
15. Pranay J and Ram-Kumar P. Antibiotic Sensitivity Pattern of Streptococcus mutans against Commercially Available Drugs. Journal of Pharmacy Research, 2009; 2(7):1250 – 1252
16. Katsuhiko M, Hirotoshi N, Kazuhiko N, Shuhei N, Ryota N and Takashi O. Amoxicillin-Resistant Oral Streptococci Identified in Dental Plaque Specimens from Healthy Japanese Adults. Journal of Cardiology, 2011; 59(3):285 – 290
17. Deepak D, Tejran K, Mukesh K and Vinod S. Antibiotic Susceptibility Pattern against Pathogenic Bacteria causing Dental Caries. Southern Asian Journal of Experimental Biology, 2011; 1(1):2011
18. *Ibrahim Zaid Al-Shami, Mohsen Ali Al-Hamzi et al. Efficacy of some Antibiotics against Streptococcus mutans Associated with Tooth Decay in Children and their Mothers. On. J. Dent. and Oral Health, 2019; 2(1):
19. Harrison GA, Rubin MP, Davies RM and Speller DC. Resistance in Oral Streptococci after repetition of a Single-Dose Amoxicillin Prophylactic regimen. Journal of Antimicrobial Chemotherapy, 1985; 15(4):501 – 503
20. Woodman AJ, Vidic J, Newman HN and Marsh PD. Effect of Repeated High Dose Prophylaxis with Amoxicillin on the Resident Oral Flora of Adult Volunteers. Journal of Medical Microbiology, 1985; 19(1):15 – 23
21. Christine C Sanders. Mechanisms Responsible for Cross-Resistance and Dichotomous Resistance among the Quinolones. Clinical Infectious Diseases, 2001; 32(1):1-8
22. Landman D, Babu E, Shah N, Kelly P, Backer M, Bratu S and Quale J. Activity of a Novel Aminoglycoside, ACHN-490, against Clinical Isolates of Escherichia coli and Klebsiella pneumonia from New York City. Journal of Antimicrobial Chemotherapy, 2010; 65(10):2123 – 2127
23. Aggen JB, Armstrong ES, Goldblum AA, Dozzo P, Linsell MS, Gliedt MJ, Hildebrandt DJ, Feeney LA, Kubo A, Matias RD et al. (2010). Synthesis and Spectrum of the Neoglycoside ACHN – 490
24. Landman D, Kelly P, Backer M, Babu E, Shah N, Bratu S, Quale J. Antimicrobial Activity of a Novel Aminoglycoside ACHN-490 against Acinetobacter baumannii and Pseudomonas aeruginosa from New York City. Journal of Antimicrobial Chemotherapy, 2011; 66:332 – 334
25. Podnecky NL, Rhodes KA and Schweizer HP. Efflux Pump-Mediated Drug Resistance in Burkholderia. Frontiers in Microbiology, 2015; 6:305
26. Kevin MK, Alisa WS, Timothy RK and Lynn EC. Aminoglycosides: An Overview. Cold Spring Habour Perspectives in Medicine, 2016; 6(6)
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