Area Under Curve by UV Spectrophotometric Method for Determination Albendazole in Bulk
The aim of present investigation is to establish simple, precise, and rapid Spectrophotometric method for the quantification of Albendazole in Active Pharmaceutical Ingredient. In this, work is carried out to for estimation of Albendazole bulk by utilizing an Area under Curve (AUC) method using UV – Visible Spectrophotometry. The study is designed to validate the developed methods as per ICH guidelines. For this purpose the wavelength range between 200-400 nm was selected. Methanolic distilled water (50 ml methanol used for stock solution and serial dilution in 25 ml distilled water) was used as a solvent throughout the work. Linearity was obtained in concentration range 2 to 10 ɥg/ml (r2 = 0.992) for the method. The developed method was found to be simple, linear, accurate, precise and highly sensitive and which can be used for routine quality control analysis for Spectrophotometric estimation of Active Pharmaceutical Ingredient.
KeywordS: Albendazole, linearity, AUC, spectrophotometer, methanol, distilled water.
3. Shivani Kala and Divya Juyal; Preformulation and characterization studies of aceclofenac active ingredient; The Pharma: 463- Innovation Journal 2016; 5(9): 110-119.
4. Beckett, A. H., Stenlake, J. B., Practical Pharmaceutical Chemistry, 4th edition, CBS Publishers and Distributors, New Delhi, 2002; 2: 275-295.
5. Rajaiya Prashant, Mishra Rakesh, Nandgude Tanaji*, Poddar Sushilkumar, Solubility and Dissolution Enhancement of Albendazole by Spherical Crystallization, ajbps. 2016, 6(52),09-14.
6. Christian G D. Analytical chemistry 6th edition, John Willey and Sons, PA, 1-2,604-620, 2003.
7. Blessy M. A review – development and stability indicating studies. Journal of Pharmaceutical Analysis, 2013.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).