Androgenic Effect and Phytochimie of the Bark of Trunk of Buchholzia coriacea Engl. (Capparidaceae)

  • R Ondele Laboratory of Biochemistry and Pharmacology of the Faculty of the. Sciences of Health. University Marien Ngouabi Republic of Congo
  • B.M.L. Peneme Laboratory of Biochemistry and Pharmacology of the Faculty of the. Sciences of Health. University Marien Ngouabi Republic of Congo
  • L. Miguel Laboratory of Biochemistry and Pharmacology of the Faculty of the. Sciences of Health. University Marien Ngouabi Republic of Congo
  • A. W. Etou Ossibi Laboratory of Biochemistry and Pharmacology of the Faculty of the. Sciences of Health. University Marien Ngouabi Republic of Congo
  • R.D.G Elion Itou Laboratory of Biochemistry and Pharmacology of the Faculty of the. Sciences of Health. University Marien Ngouabi Republic of Congo
  • C. Nkounkou Loumpangou Chemistry Unit and of the Plant Faculty of them. Sciences and Technique. University Marien Ngouabi Republic of Congo
  • A.A. Abena Laboratory of Biochemistry and Pharmacology of the Faculty of the. Sciences of Health. University Marien Ngouabi Republic of Congo

Abstract

The testosterone is the main androgen produced by the testes among the males.  Her absence is responsible for erectile dysfunction and the loss of the sexual performance. The aim of the present study is to evaluate the androgenic effect and to determine the profile phytochemestry of the barks of trunk of B. coriacea. Fifteen days after the castration, the animals left in group and, received the aqueous extract of B. coriacea (100, 250 and 500 mg/kg, p.o). The sexual parameters (mounts sexual, number of erections, number of ejaculations and the time of latency) have been valued, and compared, to the witnesses groups: water distilled (0,5 ml/100 mg, p.o) and Enanthate of testosterone (1 mg/mL, i.m). The dosage of the testosterone has been achieved by the technic of ELYSA analysis. The determination of the chemical families has been achieved by the technique of coloration in tubes. The aqueous extract of B. coriacea (100,250 and 500 mg/kg, p.o) has an effect androgenic because managed daily during 15 days, it provokes an increase of the rate plasmatic of the testosterone and the bodily weight of the rats, maintains the sexual parameters among the castrated rat, extract the number of ejaculations. The barks of trunk of B. coriacea would contain the stérols, the flavonoides, the saponosids that could be responsible for the sexual effects and androgénic observed. The aqueous extract of the plant would possess the properties androgenic would be to advise the patients presenting problems of masculine barrenness. 


Keywords:  Androgen - Phytochimie - Buchholzia - coriacea 

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References

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Ondele, R., Peneme, B., Miguel, L., Etou Ossibi, A. W., Elion Itou, R., Nkounkou Loumpangou, C., & Abena, A. (2019). Androgenic Effect and Phytochimie of the Bark of Trunk of Buchholzia coriacea Engl. (Capparidaceae). Journal of Drug Delivery and Therapeutics, 9(6), 38-42. https://doi.org/10.22270/jddt.v9i6.3664