Enhancement of solubility of Metaclopramide using solid dispersion technique with different carriers (HPβCD, PVP K-30)

  • Moumita Paul Guru Nanak Institute of Pharmaceutical Science and Technology.Kolkata-700114, West Bengal, India.
  • Pintu Sarkar BCDA College of Pharmacy and Technology, 78 Jessore Road, Hridaypur, Kolkata-700127, India
  • Riyanka Sengupta BCDA College of Pharmacy and Technology, 78 Jessore Road, Hridaypur, Kolkata-700127, India
  • Saikat Bhunia BCDA College of Pharmacy and Technology, 78 Jessore Road, Hridaypur, Kolkata-700127, India
  • Payal Jana
  • Chandan Kumar Calcutta Institute of Pharmaceutical technology & Allied .health science, Banitabla, Uluberia, Howrah-711316, India.
  • Goutam Mukhopadhyay BCDA College of Pharmacy and Technology, 78 Jessore Road, Hridaypur, Kolkata-700127, India

Abstract

Modern drug discovery has led to the development of drug molecules that exhibit high lipophilicity and poor water solubility, which leads to problematic bioavailability. Approaches have thus been made to enhance dissolution of poorly water soluble drugs through modifications and creation of specific formulations. Metaclopramide is an antiemetic and gastroprokinetic agent, commonly used to treat nausea and vomiting. It is absorbed well after oral administration but a significant first pass effect in some human patients may reduce systemic bioavailability to 30%.The Metaclopramide base is thus modified from Metaclopramide hydrochloride to enhance solubility .This has been achieved by the formulating in solid dispersion since Metaclopramide is poorly water soluble. Though it is absorbed well after oral administration, a significant first pass effect in some patients reduces systemic bioavailability, which can cause adverse side effects. This solid dispersion has then been used through transdermal drug delivery. Enhancement of solubility of poorly water soluble drug by solid dispersion may be attributed to particles modified characters such as particle size reduction, improved wettability, higher porosity, decreased lattice energy, amorphous state. The main objective thus includes modification of drug Metaclopramide  hydrochloride to Metaclopramide base, preparation of solid dispersion of modified Metaclopramide  base drug which has poor water solubility, experimental analysis of Metaclopramide base drug and solid dispersion products with carriers.


Keywords: solubility, Metaclopramide, solid dispersion, carriers, HPβCD, PVP K-30

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Author Biographies

Moumita Paul, Guru Nanak Institute of Pharmaceutical Science and Technology.Kolkata-700114, West Bengal, India.

Guru Nanak Institute of Pharmaceutical Science and Technology.Kolkata-700114, West Bengal, India.

Pintu Sarkar, BCDA College of Pharmacy and Technology, 78 Jessore Road, Hridaypur, Kolkata-700127, India

BCDA College of Pharmacy and Technology, 78 Jessore Road, Hridaypur, Kolkata-700127, India

Riyanka Sengupta, BCDA College of Pharmacy and Technology, 78 Jessore Road, Hridaypur, Kolkata-700127, India

BCDA College of Pharmacy and Technology, 78 Jessore Road, Hridaypur, Kolkata-700127, India

Saikat Bhunia, BCDA College of Pharmacy and Technology, 78 Jessore Road, Hridaypur, Kolkata-700127, India

BCDA College of Pharmacy and Technology, 78 Jessore Road, Hridaypur, Kolkata-700127, India

Payal Jana

BCDA College of Pharmacy and Technology, 78 Jessore Road, Hridaypur, Kolkata-700127, India

Chandan Kumar, Calcutta Institute of Pharmaceutical technology & Allied .health science, Banitabla, Uluberia, Howrah-711316, India.

Calcutta Institute of Pharmaceutical technology & Allied .health science, Banitabla, Uluberia, Howrah-711316, India.

Goutam Mukhopadhyay, BCDA College of Pharmacy and Technology, 78 Jessore Road, Hridaypur, Kolkata-700127, India

BCDA College of Pharmacy and Technology, 78 Jessore Road, Hridaypur, Kolkata-700127, India

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How to Cite
Paul, M., Sarkar, P., Sengupta, R., Bhunia, S., Jana, P., Kumar, C., & Mukhopadhyay, G. (2019). Enhancement of solubility of Metaclopramide using solid dispersion technique with different carriers (HPβCD, PVP K-30). Journal of Drug Delivery and Therapeutics, 9(6), 17-22. https://doi.org/10.22270/jddt.v9i6.3663