Skin Sensitization Calculation, Topical anti-inflammatory effect and DFT Study of New Indole-Hydrazone

Topical anti-inflammatory effect and DFT Study of New Indole-Hydrazone

  • Kamel Mokhnache Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria
  • Ahlem Karbab Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria
  • EL-Khamsa Soltani Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria
  • Soraya Madoui Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria
  • Hanane Khither Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria
  • Noureddine Charef Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria
  • Lekhmici Arrar Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria

Abstract

A new indol-hydrazone (IH); N'-[(E)-(5-bromo-1H- indol-3-yl) methylidene] pyridine-4-carbohydrazide was selected for theoretical and experimental studies. Molecular structure proprieties were investigated using density functional theory (DFT) via B3LYP/6-31G (d,p), skin sensitization prediction was carried out using Pred Skin software program. The obtained results demonstrate the reactivity of IH with Energy gap (Δ) of 0.0579 a.u, low sensitizer effect towards human skin with probability of 60 %, and an excellent topical anti-inflammatory effect against xylen-induced ear odema in mice model with inhibition percentages of 81.48%.


Keyword: Hydrazone, skin sensitization, Topical, Anti-inflammatory.

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How to Cite
Mokhnache, K., Karbab, A., Soltani, E.-K., Madoui, S., Khither, H., Charef, N., & Arrar, L. (2019). Skin Sensitization Calculation, Topical anti-inflammatory effect and DFT Study of New Indole-Hydrazone. Journal of Drug Delivery and Therapeutics, 9(6), 43-46. https://doi.org/10.22270/jddt.v9i6.3655

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