Synthesis and Biological Evaluation of Novel Schiff Bases of Aryloxy Moiety

  • Purushottam R. Laddha
  • Kailash R. Biyani

Abstract

Schiff's bases are condensation products of primary amines with carbonyl compounds. Schiff bases (imines) possess wide variety of biological activities that include antibacterial and antifungal activity. In present work, Schiff bases from 3,5- Dimethoxyphenol (aryloxy moiety) as starting material synthesized. Esterification of 3,5- Dimethoxyphenol led to formation of (3,5-Dimethoxy-phenoxy)-acetic acid ethyl ester (1). (3,5-Dimethoxy-phenoxy)-acetic acid hydrazide (2) is derived from Compound (1) by hydrazination. Compound (2) was reacted with different aromatic aldehydes to yield novel imines or Schiff bases (3A-I). The newly synthesized compounds were characterized on the basis of spectral studies and evaluated for antibacterial and antifungal activities. All the synthesized compounds had shown antibacterial and antifungal activity. Schiff bases 3C, 3D, 3E and 3I had shown good antimicrobial activity among all newly synthesized compounds.


Keywords: Schiff base, aryloxy moiety, imines

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Author Biographies

Purushottam R. Laddha

Department of Pharmaceutical Chemistry, Anuradha College of Pharmacy, Chikhli. Dist. Buldhana, Maharashtra, India, 443201

Kailash R. Biyani

Department of Pharmaceutical Chemistry, Anuradha College of Pharmacy, Chikhli. Dist. Buldhana, Maharashtra, India, 443201

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How to Cite
Laddha, P. R., & Biyani, K. R. (2019). Synthesis and Biological Evaluation of Novel Schiff Bases of Aryloxy Moiety. Journal of Drug Delivery and Therapeutics, 9(5-s), 44-49. https://doi.org/10.22270/jddt.v9i5-s.3635