Anti-inflammatory and healing effect of leaf-flower mixture extract of Cytisus triflorus L

  • Soraya Madoui Laboratory of Applied Biochemistry, University of Setif 19000, Setif-1, Algeria
  • Kamel Mokhnache Laboratory of Applied Biochemistry, University of Setif 19000, Setif-1, Algeria
  • Hanane Khither Laboratory of Applied Biochemistry, University of Setif 19000, Setif-1, Algeria
  • Sana Aouchria Laboratory of Applied Biochemistry, University of Setif 19000, Setif-1, Algeria
  • Noureddine Charef

Abstract

Objective: The present study aims to study the anti-inflammatory and healing effects of the crude leaf and flower mixture extract of Cytisus triflorus L., known in Algeria as Igoulli.


Methodology and results: The method consists of studying the anti-inflammatory effect by measuring the diameter of edema of the paw of rats that received carrageenan. In addition, 2 cm diameter circular incision wounds were made in rats to evaluate the healing activity of the crude leaf and flower mixture extract of Cytisus triflorus L. at doses of 200 mg/kg and 400 mg/kg. The anti-inflammatory effect of C. triflorus showed that E.Br at the dose 400 mg has the higher activity, which induces a significant decrease in the thickness of the rat paw from the second hour, its effects being similar to those of Diclofenac. The percentages of inhibition of edema at 4 h and 6 h are 80.05 and 88.56% for E.Br and Diclofenac respectively. With respect to healing activity, the results show that after 18 days, complete healing was achieved with almost two concentrations of crude C. triflorus, tissue remodeling and reoccurrence of hair was observed at level of scars.


Conclusion: The results of the study show that the leaf extract and flower extract of Cytisus triflorus L. has healing and anti-inflammatory properties that could justify the use of this plant in traditional medicine against inflammatory diseases.


Keywords: Cytisus triflorus, anti-inflammatory, healing activity.

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Author Biographies

Soraya Madoui, Laboratory of Applied Biochemistry, University of Setif 19000, Setif-1, Algeria

Laboratory of Applied Biochemistry, University of Setif 19000, Setif-1, Algeria

Kamel Mokhnache, Laboratory of Applied Biochemistry, University of Setif 19000, Setif-1, Algeria

Laboratory of Applied Biochemistry, University of Setif 19000, Setif-1, Algeria

Hanane Khither, Laboratory of Applied Biochemistry, University of Setif 19000, Setif-1, Algeria

Laboratory of Applied Biochemistry, University of Setif 19000, Setif-1, Algeria

Sana Aouchria, Laboratory of Applied Biochemistry, University of Setif 19000, Setif-1, Algeria

Laboratory of Applied Biochemistry, University of Setif 19000, Setif-1, Algeria

Noureddine Charef

Laboratory of Applied Biochemistry, University of Setif 19000, Setif-1, Algeria

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How to Cite
Madoui, S., Mokhnache, K., Khither, H., Aouchria, S., & Charef, N. (2019). Anti-inflammatory and healing effect of leaf-flower mixture extract of Cytisus triflorus L. Journal of Drug Delivery and Therapeutics, 9(6), 1-6. https://doi.org/10.22270/jddt.v9i6.3625