Anti-inflammatory and healing effect of leaf-flower mixture extract of Cytisus triflorus L
Objective: The present study aims to study the anti-inflammatory and healing effects of the crude leaf and flower mixture extract of Cytisus triflorus L., known in Algeria as Igoulli.
Methodology and results: The method consists of studying the anti-inflammatory effect by measuring the diameter of edema of the paw of rats that received carrageenan. In addition, 2 cm diameter circular incision wounds were made in rats to evaluate the healing activity of the crude leaf and flower mixture extract of Cytisus triflorus L. at doses of 200 mg/kg and 400 mg/kg. The anti-inflammatory effect of C. triflorus showed that E.Br at the dose 400 mg has the higher activity, which induces a significant decrease in the thickness of the rat paw from the second hour, its effects being similar to those of Diclofenac. The percentages of inhibition of edema at 4 h and 6 h are 80.05 and 88.56% for E.Br and Diclofenac respectively. With respect to healing activity, the results show that after 18 days, complete healing was achieved with almost two concentrations of crude C. triflorus, tissue remodeling and reoccurrence of hair was observed at level of scars.
Conclusion: The results of the study show that the leaf extract and flower extract of Cytisus triflorus L. has healing and anti-inflammatory properties that could justify the use of this plant in traditional medicine against inflammatory diseases.
Keywords: Cytisus triflorus, anti-inflammatory, healing activity.
2. Khalil N.M., Sperotto 1.S. & Manfron M.P. Anti-inflammatory activity and acute toxicity of Dodonaea viscosa. Fitoterapia, 2006; 77, 478-80.
3. Ait-Kaci Aourahoun K., Fazouane F. and Benayache S. Pharmacological potential of Cytisustriflorusl’Hérit.extracts as antioxidant and anti-inflammatory agent. Der Pharmacia Lettre. 2015; 7(5):104-110.
4. Sharma U., Sharma K., Sharma N., Sharma A., Singh H. and Sinha A. Microwave-assisted efficient extraction of different parts of Hippophaerhamnoides for the comparative evaluation of antioxidant activity and quantification of its phenolic constituents by reverse-phase highperformance liquid chromatography (RPHPLC). Journal of agricultural and foodchemistry. 2008; 56(2):374-379.
5. Winter C.A., RisleyE.A. and Nuss G.W. Carrageenin-induced oedema in hind paws of rats as an assay for antiinflammatory drugs. Proceedings of the Society for Experimental Biology and Medicine. 1962; 111:544-547.
6. Elion Itou R.D.G., Sanogo R., Etou Ossibi A.W., Nsondé Ntandou F.G., Ondelé R., Pénemé B.M., Okiémy Andissa N., Diallo D., Ouamba J.M., Abena A.A., Anti-inflammatory and analgesic effects of aqueous extract of stem bark of Ceiba pentandra Gaertn. Pharmacology & Pharmacy, 2014; 5:1113-1118.
7. Sagliyan A., Ceribasi A. O., Gunay C., Han M. C., Benzer F., Kandemir, Effects of dietary supplementation with whey proteins on surgical wound healing in rats. Revue Méd. 2010; 161(10):455-462.
8. Wantana R., Tassanee N. and Subhadhirasakul S. Antinociceptive, antipyretic, and anti-in ammatory activities of Putranjivaroxburghii Wall.leaf extract in experimental animals. Journal of Natural Medicinal. 2009; 63(3):290-296.
9. Rousselet M.C., Vignaud J.M., Hofman P. and Chatelet F.P. Inflammation et pathologie inflammatoire. Association française des enseignants et chercheurs en anatomie pathologie. 2005; 1-57.
10. Gonzalez-Gallego J., Sanchez-Campos S. and Tunon M.J. Anti-inflammatory propreties of dietary flavonoids. Nutricion Hospitalaria. 2007; 22 (3):287-293.
11. Kim J., Lee K.W. and Lee H.J. Polyphenols suppress and modulate inflammation: possible roles in health and disease. In Watson R.S., Preedy V.R. and Zibadi S. Polyphenols in human health and disease. First edition, Elsevier: Amsterdam. 2014; 393-408.
12. Corrado B., Marco T., Rocchina C., Matteo F., Luca A., Narcisa G. and Mario D.T. Role of coxibs in the strategies for gastrointestinal protection in patients requiring chronic non-steroidal anti-infllammatory therapy. Pharmacological Research . 2009; 59:90-100.
13. Suriyamoorthy S., Subramaniam K., Raj-Durai S.J, wahaab F. and Chitraselvi R.P.E. Evaluation of wound healing activity of Acacia caesia in rats. Wound Medicine. 2014; 7:1-7.
14. Lopes-Lutz D., Alviano D.S. and Kolodziejczyk P.P. Screening of chemical composition, antimicrobial and antioxidant activities of Artemisia essential oils. Phytochemistry. 2008; 69(8):1732–1738.
15. Upadhyay R.K. Plant latex: its toxicity and defense against herbivorous insects: A review International Journal of Current Research. 2012; 4(01):5-10.
16. Khadri S., Boutefnouchet N., Hadef Y. and Djerrou Z. Evaluation of the Cytisus Triflorus (Lam.) Polyphenols Cicatrizing Activity on Experimental Thermal Burns in New Zealand Rabbits. OnLine Journal of Biological Sciences. 2018; 18(3):298-303.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).