Synthesis, Characterization, Hydrolytic Cleavage, and Biological Activity Studies of 2-[(1e)-N-{2-[(2-{(Z)-[1-(2-Hydroxyphenyl)Ethylidene] Amino}Ethyl)Amino]Ethyl}Ethanimidoyl]Phenol

BIOACTIVITIES OF PHENOLIC SCHIFF BASES

  • Kamel Mokhnache Setif1 University
  • Soraya Madoui
  • Hanane Khither
  • El-Khamsa Soltani
  • Noureddine Charef
  • Arrar Lekhmici

Abstract

A Schiff base ligand 2-[(1E)-N-{2-[(2-{(Z)-[1-(2-hydroxyphenyl) ethylidene] amino}ethyl)amino]ethyl} ethanimidoyl]phenol L was hydrolyzed by copper cation which lead to formation of 8,8-dichloro-2H,3H,5H,6H-1,3-diaza-2-cupracyclopenta[1,3-a]1,3-diaza-2-cupracyclopentane hydrate (Complex), characterized by UV, IR, Powder XRD and by elemental analysis. In vitro antioxidant and anticoagulant, activities of L were evaluated. Antioxidant potential of L was assessed by DPPH scavenging, β-carotene bleaching test, hydroxyl radical scavenging method, ABTS radical scavenging test, and by reducing power test. In vitro anticoagulant effect of L at the 84 µg/mL; showed the maximum prolongation of plasma recalcification time which is comparable with that of the anticoagulant drug; heparin. In conclusion, results of the present investigation indicate that the ligand L can be a potential anticoagulant agent.


Keywords: Schiff base; Antioxidant; Free radicals; Anticoagulant.

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Author Biographies

Kamel Mokhnache, Setif1 University

Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria

Soraya Madoui

Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria

Hanane Khither

Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria

El-Khamsa Soltani

Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria

Noureddine Charef

Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria

Arrar Lekhmici

Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria

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How to Cite
Mokhnache, K., Madoui, S., Khither, H., Soltani, E.-K., Charef, N., & Lekhmici, A. (2019). Synthesis, Characterization, Hydrolytic Cleavage, and Biological Activity Studies of 2-[(1e)-N-{2-[(2-{(Z)-[1-(2-Hydroxyphenyl)Ethylidene] Amino}Ethyl)Amino]Ethyl}Ethanimidoyl]Phenol. Journal of Drug Delivery and Therapeutics, 9(5-s), 25-29. https://doi.org/10.22270/jddt.v9i5-s.3621