Study of the Association between Hypothyroidism and Non-Alcoholic Fatty Liver Disease

  • Anoop Uniyal
  • Prashant Mathur
  • Yogesh Joshi

Abstract

Aim: The aim of the present study was to investigate the association between hypothyroidism and non-alcoholic fatty liver disease (NAFLD).


Methods: In a prospective observational study, the hypothyroidism patients were evaluated for NAFLD using ultrasonography. The participant’s characteristics such as age, gender, thyroid profile, history of diabetes, hypertension, ischemic heart disease (IHD) were recorded using a data gathering form.


Results: A total of 51 participants were included in this study. From 51 participants, 47 (92.18%) individuals were females whereas 4 (7.82%) individuals were males. Out of 51 participants 27 individuals had NAFLD. There was statistically significant difference in FT4 levels with the participants with NAFLD.


Conclusion: Results from this study suggested that low FT4 concentration is associated with increased risk of NAFLD.


Keywords: Hypothyroidism, NAFLD, ultrasonography, FT4.

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Author Biographies

Anoop Uniyal

Department of Pharmacy Practice, School of Pharmaceutical Sciences, SGRR University, Patel Nagar, Dehradun, Uttarakhand, India-248001

Prashant Mathur

Department of Pharmacy Practice, School of Pharmaceutical Sciences, SGRR University, Patel Nagar, Dehradun, Uttarakhand, India-248001

Yogesh Joshi

Department of Pharmacy Practice, School of Pharmaceutical Sciences, SGRR University, Patel Nagar, Dehradun, Uttarakhand, India-248001

References

1. Sharma KK, Sharma HL. Principles of pharmacology, Paras medical publisher Hyderabad, 2nd Edition, 2011; 610-11.
2. Okita M, Hayashi M, Sasagawa T, Takagi K, Suzuki K, Kinoyama S. Effect of a moderately energy-restricted diet on obese patients with fatty liver. Nutrition. 2001; 17(7–8):542–7.
3. Roberts CG, Ladenson PW. Hypothyroidism. Lancet- a Medical Journal, 2004; 363(9411); 793–803.
4. Hypothyroidism. National Institute of Diabetes and Digestive and Kidney Diseases. March 2013. Archived from the original on 5 March 2016. Retrieved 5 March 2016.
5. Preedy, Victor. Comprehensive Handbook of Iodine Nutritional, Biochemical, Pathological and Therapeutic Aspects. Burlington: Elsevier. 2009. p. 616.
6. Bona G, Prodam F, Monzani A. Subclinical hypothyroidism in children: natural history and when to treat. Journal of Clinical Research in Pediatric Endocrinology (Review). 2013;5 Suppl 1 (4): 23–8. [PMID 23154159].
7. Fatourechi V. Subclinical hypothyroidism: an update for primary care physicians. Mayo Clinic Proceedings (Review). 2009;84 (1): 65–71. [PMID 19121255]
8. Baumgartner C, Blum MR, Rodondi N. Subclinical hypothyroidism: summary of evidence in 2014. Swiss Medical Weekly (Review). 144. [PMID 25536449]
9. Dons, Robert F, Frank HW. Endocrine and metabolic disorders clinical lab testing manual (4th ed.). Boca Raton: CRC Press.2009.
10. Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment of Pharmacology and Therapeutics. 2011; 34:274–285.
11. Milic S, Stimac D. Nonalcoholic fatty liver disease/steatohepatitis: epidemiology, pathogenesis, clinical presentation and treatment. Digestive Disease (Basel, Switzerland). 2012; 30:158–162.
12. Loomba R, Sanyal AJ. The global NAFLD epidemic. Nature Reveiws Gastroenterology and Hepatology. 2013; 10:686–690.
13. Nascimbeni F, Pais R, Bellentani S. From NAFLD in clinical practice to answers from guidelines. Journal of Hepatology. 2013; 59:859–71.
14. Bugianesi E, Leone N, Vanni E, et al. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology. 2002; v 123:134–140.
15. Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology (Baltimore, MD). 2003; 37:1202–1219.
16. Armstrong MJ, Adams LA, Canbay A, Syn WK. “Extrahepatic complications of nonalcoholic fatty liver disease”. Journal of Hepatology. 2014; 59; 1174–97.
17. Mazo DF, Lima VM, Stefano JT, Rabelo F, Faintuch J, Oliveira CP. Gluco-lipidic indices in treated hypothyroidism associated with non-alcoholic fatty liver disease. Arquivos de Gastroenterologia (Archives of Gastroenterology). 2011; 48:186–189.
18. Grattagliano I, Vendemiale G, Caraceni P, Domenicali M, Nardo B, Cavallari A, et al. Starvation impairs antioxidant defense in fatty livers of rats fed a choline-deficient diet. Journal of Nutrition. 2000; 130(9):2131–6.
19. James OF, Day CP. Non-alcoholic steatohepatitis (NASH): a disease of emerging identity and importance. Journal of Hepatology. 1998; 29(3):495–501.
20. Armstrong MJ, Houlihan DD, Bentham L, et al. Presence and severity of non-alcoholic fatty liver disease in a large prospective primary care cohort. Journal of Hepatology. 2012; 56; 234–40.
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How to Cite
Uniyal, A., Mathur, P., & Joshi, Y. (2019). Study of the Association between Hypothyroidism and Non-Alcoholic Fatty Liver Disease. Journal of Drug Delivery and Therapeutics, 9(5-s), 4-6. https://doi.org/10.22270/jddt.v9i5-s.3604