Study of Prevalence Rate, Side Effect and Co-Morbidities Associated with Current Drug Therapy in Patients Suffering with Nephrotic Syndrome

  • Abhishek Prasad SGRRU
  • Prashant Mathur

Abstract

Background: Nephrotic syndrome is a kidney disease caused by damage to the cluster of small blood vessels in the kidney. Nephrotic syndrome causes misfunctioning of the kidney that affects metabolism of the body significantly. It causes complications of blood clots, high blood cholesterol and elevated blood triglycerides, poor nutrition, high blood pressure, acute kidney failure, chronic kidney disease and various infections.


Objectives: The present investigation was objected to study prevalence rate, side effect of prescribed drugs and co-morbidity associated with current drug therapy in patient suffering with nephrotic syndrome.


Methodologies: The present observational study was conducted on 43 nephrotic syndrome patients. These patients were evaluated for effects and side effects of prescribed drugs. Co-morbidity related to drug current prescribed was assessed and prescribed drugs for co-morbidity for also assessed. Prevalence rate of nephrotic syndrome was calculated among the all investigated patients. Patients were investigated who signed consent form. Patients above 18 years of age were excluded from study.


Results: The involved 43 patients of nephrotic syndrome. These patients were prescribed with Corticosteroids (27%), Immunomodulator (8%), Immunosuppressant (5%), Diuretics (20%), ACE Inhibitors (5%), Angiotensin II receptor antagonist (5%). Co-morbidity were related to current drugs were observed and it was found that 9 (20%) patients were  suffering from asthma, 3 (7%) patients were suffering epilepsy, 1 (2%) patients were suffering from inflammatory bowel disease, 5 (11%) patients were suffering from other diseases along with nephrotic syndrome. Prevalence rate of nephrotic syndrome was found 2.38% in patients.


Conclusion: The present study revealed that the current prescribed drugs for nephrotic syndrome causes side effects that are skin infection, behavioral changes, blood in urine and decreased neutrophils. And co-morbidity of asthma, epilepsy, inflammatory bowel disease and other disease were present in patients of nephrotic syndrome. 1 patient out of every 42 investigated patients was suffering from  nephrotic syndrome.


Keywords: Nephrotic syndrome, corticosteroids, side effects, co-morbidity and prevalence rate.

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Author Biographies

Abhishek Prasad, SGRRU

Department of Pharmacy Practice, School of Pharmaceutical Sciences, Shri Guru Ram Rai University, Patel Nagar, Dehradun, Uttarakhand, 248001, India.

Prashant Mathur

Department of Pharmacy Practice, School of Pharmaceutical Sciences, Shri Guru Ram Rai University, Patel Nagar, Dehradun, Uttarakhand, 248001, India.

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How to Cite
Prasad, A., & Mathur, P. (2019). Study of Prevalence Rate, Side Effect and Co-Morbidities Associated with Current Drug Therapy in Patients Suffering with Nephrotic Syndrome. Journal of Drug Delivery and Therapeutics, 9(5-s), 11-17. https://doi.org/10.22270/jddt.v9i5-s.3589