CONTRACEPTIVE VAGINAL SUPPOSITORY CONTAINING nONOXYNOL-9 AND ZINC ACETATE SALT IN A CLINICAL TRIAL

  • Sarhan Hatem
  • El-adway Ahmed Department of gynecology, Faculty of Medicine, Minia University, Minia, Egypt.
  • Mohamed Soad Department of gynecology, Faculty of Medicine, Minia University, Minia, Egypt.

Abstract

Nonoxynol-9 (N-9) is the most common active ingredient of spermicides. Spermicides containing N-9 are available in many forms, such as jelly, films, suppositories and foams. The two major problems reported on using N-9 spermicide were high failure and high irritation rates which were the main causes of its withdrawing from markets and as we know local methods of contraception (condoms and vaginal suppositories) have high acceptability especial in short term use. We tried to modify N-9 products in a new formula which is safe, and effective. The new preparation based on the addition of low concentrations of zinc acetate salt (Zn (OAC)2) to N-9 that reduce the irritation of mucous membranes on frequent use and increase the efficacy of N-9. The new preparation made in the form of vaginal foaming suppository.  It was tested in-vitro and in-vivo. The in-vitro results show a significant increase in efficacy of the combination (Zn (OAC)2 & N-9) than N-9 alone. Additionally, the in-vivo results indicated a significant decrease in failure and irritation rates in the combination than (N-9 alone) market suppository.

Key words: Contraceptive, Nonoxynol-9, Zinc acetate, irritation and efficacy

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1.
Hatem S, Ahmed E- adway, Soad M. CONTRACEPTIVE VAGINAL SUPPOSITORY CONTAINING nONOXYNOL-9 AND ZINC ACETATE SALT IN A CLINICAL TRIAL. JDDT [Internet]. 14Jan.2013 [cited 25Feb.2020];3(1). Available from: http://jddtonline.info/index.php/jddt/article/view/354