Formulation and Evaluation of Teneligliptin and Telmisartan Bilayer Tablets for the Treatment of Coexistent Type II Diabetes Mellitus and Hypertension

  • Gaurav S. Lodha
  • Satyam Z Chemate

Abstract

In the current scenario type two diabetes mellitus and hypertension have become prevalent in large number of population. But there are many patients which are suffering from Type II Diabetes Mellitus as well as hypertension. Such condition is called co-existent Type II Diabetes Mellitus and Hypertension. In the present work an attempt is made to treat co-existent type II Diabetes Mellitus and hypertension by formulating a Bilayer tablet of Teneligliptin and Telmisartan. Both drugs are sustained released to give a day long relief to the patients and to also reduce the dose frequency. Both the layers of the tablets were formulated by wet granulation method. The granules were tested for angle of repose, bulk density, tapped density, compressibility and Hausner’s ratio to check their efficacy. Eleven different types of formulations were made using various polymers and excipients with the drugs such as PVP K30, HPMC K4M, Starch, Crospovidone, Lactose, Mannitol, Talc and Magnesium Stearate. From these 11 formulations F6 showed better tablet characteristics and drug release rate than other formulations. Thus F6 is the best formulation in this study. Biological screening of the drugs combination of Teneligliptin and Telmisartan was also done to check the presence of antidiabetic activity of the combination which showed positive results.


Keywords: - Teneligliptin, Telmisartan, Sustained, Bilayer. 

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How to Cite
Lodha, G. S., & Chemate, S. Z. (2019). Formulation and Evaluation of Teneligliptin and Telmisartan Bilayer Tablets for the Treatment of Coexistent Type II Diabetes Mellitus and Hypertension. Journal of Drug Delivery and Therapeutics, 9(5), 26-38. https://doi.org/10.22270/jddt.v9i5.3537