Preformulation Studies of Rapid Dissolving Films Containing Granisetron Hydrochloride

  • Alok Khunteta
  • Manish Kumar Gupta
  • Surendra Kumar Swarnkar

Abstract

Rapid-dissolving solid drug dosage forms for application onto the oral cavity for the pediatric population seem to be very appropriate, especially in preterm and term infants. The delivery of drugs via the oral mucosa offers easy application, prevents drug degradation by gastrointestinal fluids, avoids first-pass metabolism and potentially improves bioavailability. Granisetron hydrochloride (GSH) drug is used as antiemetic agent. Proposed work comprise of preformulation studies of Granisetron hydrochloride. For that, physicochemical parameters were determined; like melting point of GSH was determined using melting point apparatus, Granisetron hydrochloride was scanned in the distilled water, Acid buffer, pH 1.2 and Phosphate buffer, pH 6.8. The IR spectrum of pure drug (GSH), Pullulan, METHO K3P, METHO E3P, METHO E15P and POLYOX WSR N10 were recorded in potassium bromide using Shimadzu FTIR – 8400S(CE). Solubility of Granisetron hydrochloride was determined using shake flask method. Standard Plot of Granisetron hydrochloride in distilled water, Acid buffer, pH 1.2 and Phosphate buffer, pH 6.8 were taken, all the parameter obtained were satisfactory, which will be used further for formulation of rapid dissolving film.


Keywords: Rapid dissolving film, Granisetron hydrochloride (GSH), Preformulation.

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How to Cite
Khunteta, A., Gupta, M. K., & Swarnkar, S. K. (2019). Preformulation Studies of Rapid Dissolving Films Containing Granisetron Hydrochloride. Journal of Drug Delivery and Therapeutics, 9(4-A), 511-515. https://doi.org/10.22270/jddt.v9i4-A.3524

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