Development and Validation of UV-Spectrophotometric Method for Estimation of Metformin Hydrochloride and Pioglitazone in Tablet Dosage Form

  • Rupali S. Joshi
  • Ajit K. Nangare
  • Deepali S. Sanap
  • Surekha M. Sase

Abstract

Simple, sensitive, rapid and accurate UV spectroscopic methods have been developed for the estimation of metformin hydrochloride and pioglitazone in tablet dosage forms. Simultaneous estimation and dual-wavelength methods were developed and validated using solvent methanol. Both drugs show linearity at 5-40 µg/ml for both methods. The suggested techniques have been effectively implemented in pharmaceutical formulations to the evaluation of quoted drugs. Recovery research was conducted to verify the method's accuracy, precision. The techniques have been validated under ICH guidelines.


Keywords: Metformin hydrochloride, Pioglitazone, Simultaneous estimation method and Dual wavelength method.

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Joshi RS, Nangare AK, Sanap DS, Sase SM. Development and Validation of UV-Spectrophotometric Method for Estimation of Metformin Hydrochloride and Pioglitazone in Tablet Dosage Form. JDDT [Internet]. 30Aug.2019 [cited 17Feb.2020];9(4-A):381-4. Available from: http://jddtonline.info/index.php/jddt/article/view/3499