Evaluation of Methanolic Extract of Clitoria ternatea Hepatoprotective & Nephroprotective Activity in Rats

  • Srikanta Chandra

Abstract

Objective: The aim of the study was to investigate the nephroprotective & hepatoprotective activity of methanolic extract of  Clitoria ternatea  in Cisplatin & CCl4 induced in rats


Methods: Methanolic extract of aerial part of Clitoria ternatea  plant was studied  for its Nephroprotective  & Hepatoprotective activity in animal experiment models. Nephrotoxicity was induced by Cystone  16 mg/kg b.w . Standard drug was taken Silymarin .Test drug were given methanolic extract   Clitoria ternatea   500 mg/kg , 1000 mg/kg  . Hepatoxicity was induced by CCl4 .Standard drug was taken cisplatin 100 mg/kg . Test drugs were given extract of  Clitoria ternatea 500 mg/kg  & 1000 mg/kg as per b.w


Results : In Hepatoprotective activity positive control group was provided with CCl4 and increased SGPT , SGOT , ALP level compare to negative control group whereas Test(2) group was  provided with methanolic extract of Clitoria ternatea  1000 mg/kg decreased SGPT , SGOT , ALP level compare to standard group. In nephroprotective activity positive control group was provided with CCl4 increased Urea and creatinine level where as Test(2) group are provided with methanolic extract of  Clitoria ternatea 1000 mg/kg decreased urea and creatinine level


Conclusion: On evaluating biochemical parameters it was found that methanolic extract of Clitoria ternatea 1000 mg/kg showed hepatoprotective and nephroprotective activity in rats.  


Keywords:  SGPT, SGOT, ALP, Nephroprotective, Hepatoprotective 

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Author Biography

Srikanta Chandra

Assistant Professor of Jakir Hossain Institute of Pharmacy, Department of Pharmacology ,Raghunathganj, Murshidabad, West Bengal,742225

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How to Cite
Chandra, S. (2019). Evaluation of Methanolic Extract of Clitoria ternatea Hepatoprotective & Nephroprotective Activity in Rats. Journal of Drug Delivery and Therapeutics, 9(4-A), 313-319. https://doi.org/10.22270/jddt.v9i4-A.3478