Bioavailability Enhancement of Curcumin via Mucoadhesive Drug Delivery System
The main aim of this study was to improve the bioavailability of curcumin through buccal route using mucoadhesive drug delivery. Curcumin is practically insoluble in water. After oral administration, most part of the drug was metabolism in liver .Therefore an attempt has been made to improve the bioavailability by using different concentration of sodium lauryl sulphate as bioenhancer. Buccal bilayer tablets were prepared by direct compression with different ratio of HPMC.K4M.as bioadhesive polymer and ethyl cellulose as backing layer. The formulation were characterized for various physiochehimical parameter such as weight variation, thickness, hardness, fribality, mucoadhisive strength, drug content, swelling studies and in vitro diffusion studies. The best mucoadhesive performance and In vitro drug release profile exhibited by tablets containing hydroxyproply methylcellulose K4M (5%) and Sodium louryl sulphate (0.1%).To conclude that the formulated unidirectional, bilayered, buccoadhesive tablet for curcumin using HPMC as mucoadhesive agent is superior to oral conventional tablet, as it has the potential to bypass the first pass metabolism and improve the bioavailability of curcumin.
Keywords: Curcumin, Ethyl cellulose, Sodium Lauryl Sulphate, HPMC.
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