Ameliorative effect of Ipomoea pes-caprae ethanolic leaf extract on carbohydrate metabolizing enzymes and oxidative status in Streptozotocin-induced diabetic Wistar rats

  • S. Suhasini
  • C. Elanchezhiyan
  • G. Chandirasegaran

Abstract

In diabetic patients, hyperglycemia is developed due to increased hepatic glucose production and impaired utilization of glucose in cells, which leads to oxidative stress in cells. Ipomoea pes-caprae has been widely used as an oral treatment for many diseases. The aim of the present study is to assess the effect of Ipomoea pes-caprae ethanolic leaf extract on carbohydrate metabolizing enzymes and oxidative status in Streptozotocin (STZ) induced experimental diabetic rats. Experimental diabetic rats were induced by intraperitoneal administration of 55 mg/kg b.w of STZ. Diabetic rats were treated with I. pes-caprae ethanolic leaf extract at a concentration of 300 mg/kg b.w and glibenclamide (6 mg/kg b.w) for 45 days. Diabetic rats exhibited significant (P < 0.05) decline in the activity of glucokinase and glucose-6-phosphate dehydrogenase, enzymatic antioxidants (SOD, CAT and GPx) and non-enzymatic antioxidants (GSH, vitamin E and vitamin C), while lipid peroxidation markers (LOOH and TBARS) and glucose-6-phosphatase and fructose-1, 6-bisphosphatase were found to be significantly increased. Further in diabetic rats, the histopathology of pancreas, liver and kidney showed abnormal histo-architecture. The treatment with Ipomoea pes-caprae ethanolic leaf extract notably reversed the abnormal levels in carbohydrate metabolizing enzymes, restored the oxidative status and abnormal structures in pancreas, liver and kidney to near normal levels.


Keywords: Diabetes, antioxidant, lipid peroxidation, Ipomoea pes-caprae and carbohydrate metabolizing enzymes.

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Suhasini, S., Elanchezhiyan, C., & Chandirasegaran, G. (2019). Ameliorative effect of Ipomoea pes-caprae ethanolic leaf extract on carbohydrate metabolizing enzymes and oxidative status in Streptozotocin-induced diabetic Wistar rats. Journal of Drug Delivery and Therapeutics, 9(4-A), 167-175. https://doi.org/10.22270/jddt.v9i4-A.3448