Topical Anti-inflammatory evaluation of new hydrazone: 4-chloro-3-nitrobenzylidene) isonicotinohydrazide

Topical Anti-inflammatory evaluation

  • Kamel Mokhnache Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria
  • Ahlem Karbab Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria
  • Soraya Madoui Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria
  • Hanane Khither Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria
  • EL-Khamsa Soltani Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria
  • Noureddine Charef Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria
  • Lekhmici Arrar Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria

Abstract

The anti-inflammatory effects of the investigated compounds; Isoniazid, hydrazone, and Indomethacin were evaluated in this study. The experiment was performed using xylene induced topical ear edema method in mice model, at the dose of (0.5 mg/ear). Results showed that the compounds; Isoniazid, hydrazone, and Indomethacin exerted 85, 90 and 89% of inhibition percentages, respectively. The effect of hydrazone was statistically similar to the effect of indomethacin which is a standard anti-inflammatory drug.


Keywords: inflammation, hydrazone, ear edema, topical.

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Author Biographies

Kamel Mokhnache, Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria

Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria

Ahlem Karbab, Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria

Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria

Soraya Madoui, Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria

Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria

Hanane Khither, Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria

Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria

EL-Khamsa Soltani, Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria

Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria

Noureddine Charef, Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria

Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria

Lekhmici Arrar, Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria

Laboratory of Applied Biochemistry, University Ferhat Abbas Setif 1, 19000, Algeria

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How to Cite
Mokhnache, K., Karbab, A., Madoui, S., Khither, H., Soltani, E.-K., Charef, N., & Arrar, L. (2019). Topical Anti-inflammatory evaluation of new hydrazone: 4-chloro-3-nitrobenzylidene) isonicotinohydrazide. Journal of Drug Delivery and Therapeutics, 9(5-s), 1-3. https://doi.org/10.22270/jddt.v9i5-s.3433