Topical Anti-inflammatory evaluation of new hydrazone: 4-chloro-3-nitrobenzylidene) isonicotinohydrazide
Topical Anti-inflammatory evaluation
The anti-inflammatory effects of the investigated compounds; Isoniazid, hydrazone, and Indomethacin were evaluated in this study. The experiment was performed using xylene induced topical ear edema method in mice model, at the dose of (0.5 mg/ear). Results showed that the compounds; Isoniazid, hydrazone, and Indomethacin exerted 85, 90 and 89% of inhibition percentages, respectively. The effect of hydrazone was statistically similar to the effect of indomethacin which is a standard anti-inflammatory drug.
Keywords: inflammation, hydrazone, ear edema, topical.
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