AN EFFICIENT, GREEN, CATALYST FREE SYNTHESIS AND CRYSTALLOGRAPHIC STUDY OF BENZO-4H-PYRANS IN AQUEOUS MEDIUM

  • SEKAR SILAMBU SILAMBARASAN RESEARCH SCHOLAR
  • A. Jamal Abdul Nasser

Abstract

A highly efficient and environmentally benign for the synthesis a of 2-amino-7-hydroxy-4-aryl-4H-chromene-3-carbonitrile derivatives (4a-n) in good to high yields (90%-97%) by one-pot three-component Michael addition reaction of malononitrile, aromatic aldehydes and resorcinol under reflux condition was developed in aqueous medium. Single crystal X-ray studies show that 4h crystallizes in the formula C22H15Cl2N2O2, Mr=410.26, Monoclinic, Space group P2(1)/c, a=12.753(9)Å, b=6.665(4)Å, c=24.050(14) Å, β=102.95(3)A° and 4i C16H10Cl2N2O2, Mr=333.16, Triclinic, Space group P-1, a=6.271(3)Å, b=18.697(5)Å, c =13.794(7) Å,  β =94.269(17)A°. The structure of the products were further confirmed by 1H NMR, 13C NMR, IR and Mass spectrum.


Keywords: Benzopyrans, malononitrile, resorcinol, Michael addition, water mediated synthesis, single crystal XRD

Downloads

Download data is not yet available.

Author Biography

A. Jamal Abdul Nasser

a Department of Chemistry, Jamal Mohamed College, Tiruchirappalli 620020, Tamil Nadu, India.

Statistics
19 Views | 52 Downloads
How to Cite
SILAMBARASAN, S., & Abdul Nasser, A. J. (2019). AN EFFICIENT, GREEN, CATALYST FREE SYNTHESIS AND CRYSTALLOGRAPHIC STUDY OF BENZO-4H-PYRANS IN AQUEOUS MEDIUM. Journal of Drug Delivery and Therapeutics, 9(4-A), 280-289. https://doi.org/10.22270/jddt.v9i4-A.3418