A BENIGN SYNTHESIS OF 2-AMINO-3-CYANO-4H-BENZOPYRANS VIA DOMINO REACTION

  • SEKAR SILAMBU SILAMBARASAN RESEARCH SCHOLAR
  • A. Jamal Abdul Nasser

Abstract

A green and operationally simple approach domino reaction has been developed for the synthesis of 2-amino-3-cyano- 4H-chromene derivatives from aromatic aldehydes, resorcinol and malononitrile in aqueous medium. This work represents the first example of catalyst free and organic solvents free multi-component reactions for the synthesis of pharmaceutically important chromene derivatives. The structures of the synthesized compounds were confirmed by 1H NMR, 13C NMR, IR, Mass and single crystal XRD.


 Keywords: Benzopyrans, malononitrile, Michael addition reaction, domino reaction, water mediated synthesis.

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Author Biography

A. Jamal Abdul Nasser

a Department of Chemistry, Jamal Mohamed College, Tiruchirappalli 620020, Tamil Nadu, India.

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How to Cite
SILAMBARASAN, S., & Abdul Nasser, A. J. (2019). A BENIGN SYNTHESIS OF 2-AMINO-3-CYANO-4H-BENZOPYRANS VIA DOMINO REACTION. Journal of Drug Delivery and Therapeutics, 9(4-A), 271-279. https://doi.org/10.22270/jddt.v9i4-A.3417