SUSTAINED RELEASE MATRIX TYPE DRUG DELIERY SYSTEM: A REVIEW

  • Manish Jaimini Dept. of Pharmaceutics Jaipur College of Pharmacy,Sitapura Jaipur, (Raj)-302022 Rajasthan University of Health Science, Jaipur, Rajasthan-302022
  • Abhay Hareshbhai Kothari Dept. of Pharmaceutics Jaipur College of Pharmacy,Sitapura Jaipur, (Raj)-302022 Rajasthan University of Health Science, Jaipur, Rajasthan-302022

Abstract

Oral sustained release (SR) products provide an advantage over conventional dosage forms by optimizing bio-pharmaceutics, pharmacokinetics and Pharmacodynamic properties of drugs in such a way that it reduce dosing frequency to an extent that once daily dose is sufficient for penetration, polymer swelling, drug dissolution, drug diffusion and matrix erosion. Highly water soluble drugs like Diltiazem; Ranitidine has been formulated as sustained release matrix tablets. This article contains the basic information regarding design sustained release formulation and also the different types of the same. Developing oral sustained release matrix tablet with constant release rate has always been a challenge to the pharmaceutical technologist. Most of drugs, if not formulated properly, may readily release the drug at a faster rate, and are likely to produce toxic concentration of the drug on oral administration. Hydrophilic polymers have become product of choice as an important ingredient for formulating sustained release formulations.

Key Words: Matrix system, Controlled drug delivery, Polymers.

 

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Author Biographies

Manish Jaimini, Dept. of Pharmaceutics Jaipur College of Pharmacy,Sitapura Jaipur, (Raj)-302022 Rajasthan University of Health Science, Jaipur, Rajasthan-302022
Department of pharmaceutics
Abhay Hareshbhai Kothari, Dept. of Pharmaceutics Jaipur College of Pharmacy,Sitapura Jaipur, (Raj)-302022 Rajasthan University of Health Science, Jaipur, Rajasthan-302022
Department of pharmaceutics
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How to Cite
Jaimini, M., & Kothari, A. (2012). SUSTAINED RELEASE MATRIX TYPE DRUG DELIERY SYSTEM: A REVIEW. Journal of Drug Delivery and Therapeutics, 2(6). https://doi.org/10.22270/jddt.v2i6.340