ANTIDIABETIC AND ANTIDYSLIPIDEMIC PROPERTIES OF GOA-111, A MIXTURE OF GYMNEMA SYLVESTRAE, OCIMUM SANCTUM AND AZADIRACHTA INDICA EXTRACT IN THE RATIO OF 1:1:1 STUDIED IN HIGH FAT DIET FED- LOW DOSE STREPTOZOTOCIN INDUCED EXPERIMENTAL TYPE 2 DIABETES IN RAT
Diabetes mellitus emerges from multiple biochemical and cellular impairments, including decreased insulin secretion from the pancreatic β-cells and impaired insulin action in peripheral tissues. The present study was systematically carried out to evaluate antidiabetic and antidyslipidemic properties of GOA-111,a herbal extract containing a mixture of Gymnema sylvestrae, Ocimum sanctum leaves and seed kernel of Azadirachta indica in the ratio of 1:1:1 in ameliorating both the primary and secondary complications of type 2 diabetes mellitus in high fat diet fed low dose streptozotocin induced diabetic rats
Experimental type 2 diabetes was induced with a low dose streptozotocin in rats fed on a high fat diet. Diabetic rats were treated with three different doses GOA 111 (150,300 and 450 mg/Kg b.wt/rat/day) for 30 days. The toxicological parameters such as AST, ALT and ALP were assayed. Biochemical parameters such as fasting blood glucose, glycosylated hemoglobin, insulin, insulin resistance and lipid profile were measured.
Oral treatment with GOA 111 significantly decreased the elevated levels of fasting glucose, glycosylated hemoglobin, AST, ALT and ALP. The insulin level was improved in insulin resistant diabetic rats. GOA 111 also normalized the lipid profile.
Though the results showed a dose dependent impact on the parameters, a dose of 300mg/Kg B/W/rat/day GOA 111 exerts maximum potential anti-hyperglycemic and antidyslipidemic effects in HFD/STZ-induced type 2 diabetic rats.
Key words: GOA 111; High fat diet; Streptozotocin; antidiabetic; antidyslipidemic
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