Formulation Development and Evaluation of Floating Wax Beads of Olopatadine Hydrochloride

  • Priyanka Baviskar
  • Prashant Patil
  • Ravindranath B Saudagar

Abstract

In this study, a multiple-unit gastroretentive sustain release drug delivery system of Olopatadine hydrochloride was developed from a completely aqueous environment, avoiding the use of any organic solvent, thus releasing the drug for a prolonged duration of time. Emulsion gelation technique was used to prepare beads. The beads with edible oil were prepare by mixing and homogenizing olive oil and water containing pectin and molten wax which was then extruded in to calcium chloride solution. The effects of carnauba wax on drug entrapment efficiency, floating lag time and morphology and drug release was studied. It was found that carnauba wax was sufficient to sustain the drug release at gastric pH. The results show that these beads can entrap drug in sufficient amount and also can successfully deliver the drug in stomach for a prolong duration of time avoiding the use of any organic solvent.


Keywords: Gastroretentive, Floating Wax Beads, Olopatadine

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Author Biographies

Priyanka Baviskar

Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjanery, Nashik, India

Prashant Patil

Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjanery, Nashik, India

Ravindranath B Saudagar

Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjanery, Nashik, India.

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How to Cite
1.
Baviskar P, Patil P, Saudagar RB. Formulation Development and Evaluation of Floating Wax Beads of Olopatadine Hydrochloride. JDDT [Internet]. 19Aug.2019 [cited 6Jul.2020];9(4-s):569-76. Available from: http://jddtonline.info/index.php/jddt/article/view/3384