SELF DOUBLE EMULSIFYING DRUG DELIVERY SYSTEM (SDEDDS): A REVIEW

  • Atul Padole Gurunanak College of Pharmacy, Nagpur University, Nagpur, India-440026
  • Mitali Bodhankar Gurunanak College of Pharmacy, Nagpur University, Nagpur, India-440026

Abstract

Self emulsifying drug delivery systems (SEDDS) are well known for its potential to improve the aqueous solubility and oral absorption of lipophilic drugs. Self double-emulsifying drug delivery system (SDEDDS) are basically used for drugs having low solubility in water, but its potential application for the drugs defined as “high solubility low permeability class†or a biopharmaceutical classification system [BCS] class III drug is appreciable, in which gastrointestinal permeation is the rate controlling step in the absorption process. The most important factor affecting the oral absorption of a drug, besides dissolution, is the permeability of the drug across the gastrointestinal lining. Improving permeability may, therefore, potentially improve the bioavailability of a drug. In this review we discuss the preparation, stability, formulation and characterization of SDEDDS.

 

Key Words: Multiple emulsion, self emulsifying, Protein peptide drug delivery, High soluble poorly permeable drugs.

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How to Cite
Padole, A., & Bodhankar, M. (2012). SELF DOUBLE EMULSIFYING DRUG DELIVERY SYSTEM (SDEDDS): A REVIEW. Journal of Drug Delivery and Therapeutics, 2(6). https://doi.org/10.22270/jddt.v2i6.336