Effect of Hydroalcoholic Extract of Dactylorhiza Hatagirea Roots & Lavandula Stoechas Flower on Thiopental Sodium Induced Hypnosis in Mice
Abstract
Dactylorhiza hatagirea (D.Don) Soo belongs to the family orchidaceae. The plant is native and near endemic to Indian Himalayan region. Its distribution extends to Pakistan, Afghanistan, Nepal, Tibet and Bhutan. In India, it is reported from Jammu and Kashmir, Sikkim, Arunachal Pradesh, Uttarakhand and Himachal Pradesh. The Juice extracted from tuber is used as tonic and also used for the treatment of pyorrhea (inflammation of the gum & teeth). Root paste is externally applied as poultice on cuts and wounds and extract is given in intestinal disorders. Lavandula stoechas, the Spanish lavender or topped lavender or French lavender is a species of flowering plant in the family lamiaceae, ccurring naturally in several Mediterranean countries, including France, Spain, Portugal, Italy and Greece. It is used commercially in air fresheners and insecticides. Flower spikes have been used internally for headaches, irritability, feverish colds and nausea and externally for wounds, rheumatic pain, antiseptic, digestive, antispasmodic, healing, insect repellent and antibacterial. The neuropharmacological activities were examined by thiopental sodium induced sleeping time in mice at the doses of 100, 200 and 300 mg/kg p.o body weight. All the extracts exhibited significant reduction of onset and duration of sleep in thiopental sodium induced sleeping time test. Altogether, these results suggest that experimental hydroalcoholic extracts of D. hatagirea roots & L. stoechas flower possesses potent hypnotic properties, which support its use in traditional medicine.
Keywords: Dactylorhiza hata, Lavandula stoechas, Sleeping time test, Thiopental sodium
Downloads
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.