Formulation and Evaluation of Ritonavir Immediate Release Tablets by Hot Melt Extrusion Method

KEY WORDS: Ritonavir, HPMC, Ethyl cellulose, Copovidone immediate release tablets.

  • Shaik. Md. Zakir Hussain
  • J. Shiva
  • Goli Venkateswarlu Mr
  • D Suthakaran
  • Syed Ghouse

Abstract

In the present work, an attempt has been made to develop immediate release coated tablets of Ritonavir by hot met extrusion method using 16 station rotary tablet punching machine. The blend of all the formulations showed good flow properties such as bulk density, tapped density. The prepared IR coated tablets of ritonavir shown good post compression parameters. They passed all the quality control evaluation parameters as per USP limits. Among all the formulations, F5 formulation showed maximum % drug release i.e., 99 % in 120 mins hence it is considered as optimized formulation. The optimized formulation was compared to innovator tablets.


Keywords: Ritonavir, HPMC, Ethyl cellulose, Copovidone immediate release tablets.

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Author Biographies

Shaik. Md. Zakir Hussain

Department of pharmaceutics Smt Sarojini Ramulamma College of pharmacy-Mahabubnagar-T.S.

J. Shiva

Assistant professor. Pharmaceutics, Vijaya College of pharmacy, Hayathnagar (m), Hyderabad. –T.S.

Goli Venkateswarlu, Mr

Department of pharmaceutical biotechnology Vijaya College of pharmacy, Hayathnagar (m), Hyderabad. –T.S.

D Suthakaran

Professor. Pharmaceutical chemistry, Vijaya College of pharmacy, Hayathnagar (m), Hyderabad. –T.S.

Syed Ghouse

Assistant professor. Pharmaceutical Analysis, Vijaya College of pharmacy, Hayathnagar (m), Hyderabad. –T.S

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How to Cite
Hussain, S. M. Z., Shiva, J., Venkateswarlu, G., Suthakaran, D., & Ghouse, S. (2019). Formulation and Evaluation of Ritonavir Immediate Release Tablets by Hot Melt Extrusion Method. Journal of Drug Delivery and Therapeutics, 9(4-A), 63-71. https://doi.org/10.22270/jddt.v9i4-A.3293