Formulation and Evaluation of Ritonavir Immediate Release Tablets by Hot Melt Extrusion Method
KEY WORDS: Ritonavir, HPMC, Ethyl cellulose, Copovidone immediate release tablets.
In the present work, an attempt has been made to develop immediate release coated tablets of Ritonavir by hot met extrusion method using 16 station rotary tablet punching machine. The blend of all the formulations showed good flow properties such as bulk density, tapped density. The prepared IR coated tablets of ritonavir shown good post compression parameters. They passed all the quality control evaluation parameters as per USP limits. Among all the formulations, F5 formulation showed maximum % drug release i.e., 99 % in 120 mins hence it is considered as optimized formulation. The optimized formulation was compared to innovator tablets.
Keywords: Ritonavir, HPMC, Ethyl cellulose, Copovidone immediate release tablets.
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