SOLUBILITY ENHANCEMENT METHODS WITH IMPORTANCE OF HYDROTROPY
The effectiveness of formulation depends particularly on how efficiently is drug available at the site of action. Therapeutic effectiveness of a drug basically depends upon bioavailability and the solubility of drug moiety. Â Most of the chemical entities that are being discovered are lipophilic and have poor aqueous solubility. A more than 40% drug suffers from poor water solubility. Currently number of techniques addressed the enhancement of solubility and dissolution rate of poorly soluble drugs. Hydrotropic solubilization is one of them. Hydrotropy is a solubilization phenomenon whereby addition of large amounts of a second solute results in an increase in the aqueous solubility of another solute. A hydrotrope is a compound that solubilises hydrophobic compounds in aqueous solutions. To solubilize water insoluble drugs especially in case of oral formulation, solubility remains a critical factor so for in this review various solubility enhancement techniques are highlighted and a brief review of hydrotropy and its preparation are discussed.
Keywords: - Solubility, Hydrotropy, Mixed hydrotropy
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).