SOLUBILITY ENHANCEMENT METHODS WITH IMPORTANCE OF HYDROTROPY

  • Md. Sajid ali
  • Vicky Choudhary School of Pharmaceutical Sciences, Shoolini University, Solan (H.P.), India

Abstract

The effectiveness of formulation depends particularly on how efficiently is drug available at the site of action. Therapeutic effectiveness of a drug basically depends upon bioavailability and the solubility of drug moiety.  Most of the chemical entities that are being discovered are lipophilic and have poor aqueous solubility. A more than 40% drug suffers from poor water solubility. Currently number of techniques addressed the enhancement of solubility and dissolution rate of poorly soluble drugs. Hydrotropic solubilization is one of them. Hydrotropy is a solubilization phenomenon whereby addition of large amounts of a second solute results in an increase in the aqueous solubility of another solute. A hydrotrope is a compound that solubilises hydrophobic compounds in aqueous solutions. To solubilize water insoluble drugs especially in case of oral formulation, solubility remains a critical factor so for in this review various solubility enhancement techniques are highlighted and a brief review of hydrotropy and its preparation are discussed.

Keywords: - Solubility, Hydrotropy, Mixed hydrotropy

Downloads

Download data is not yet available.

Author Biography

Md. Sajid ali
PHARMACEUTICAL SCIENCES
Statistics
120 Views | 403 Downloads
How to Cite
ali, M., & Choudhary, V. (2012). SOLUBILITY ENHANCEMENT METHODS WITH IMPORTANCE OF HYDROTROPY. Journal of Drug Delivery and Therapeutics, 2(6). https://doi.org/10.22270/jddt.v2i6.329