Formulation and Evaluation of FSM-Alginate Beads of Vildagliptin

  • ABIYA SARA CHERIAN M.PHARM STUDENT
  • G Boby Johns
  • R Praveen Raj
  • P.A Daisy
  • Samuel Jeny

Abstract

Many approaches have been immerged to prolong the residence time of the dosage forms at the absorption site .One among them is the development of oral controlled release mucoadhesive system. The present study aims to formulate and evaluate the effectiveness of FSM-Alginate beads of Vildagliptin in streptozotocin induced diabetic rats. In the present work, 6 formulations of Vildagliptin mucoadhesive beads (F1 to F6) were prepared by ionotropic gelation method. Fenugreek seed mucilage and sodium alginate was used as polymers and calcium chloride as cross linking agent. The beads containing drugs and excipients were subjected to various evaluation test such as Particle size distribution, Swelling index, Mucoadhesivity and Dissolution studies. Among all the formulations, F3 containing FSM and sodium alginate in the concentration of 0.6g and % DEE of 97.89 resulting in the highest drug release rate of 97.86% at the end of 10 h. Hence, it was considered as the optimized formulation.


Keywords: Mucoadhesion, Fenugreek Seed Mucilage, Sodium Alginate, Diabetes. Ionotropic Gelation.

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Author Biographies

G Boby Johns

Department of Pharmaceutics, St Joseph’s College of Pharmacy Chertahla, Alappuzha, Kerala, India, - 688524

R Praveen Raj

Department of Pharmaceutics, St Joseph’s College of Pharmacy Chertahla, Alappuzha, Kerala, India, - 688524

P.A Daisy

Department of Pharmaceutics, St Joseph’s College of Pharmacy Chertahla, Alappuzha, Kerala, India, - 688524

Samuel Jeny

Department of Pharmaceutics, St Joseph’s College of Pharmacy Chertahla, Alappuzha, Kerala, India, - 688524

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How to Cite
CHERIAN, A., Boby Johns, G., Praveen Raj, R., Daisy, P., & Jeny, S. (2019). Formulation and Evaluation of FSM-Alginate Beads of Vildagliptin. Journal of Drug Delivery and Therapeutics, 9(4-A), 246-251. https://doi.org/10.22270/jddt.v9i4-A.3289