FORMULATION DEVELOPMENT AND EVALUATION OF GASTRO RETENTIVE FLOATING TABLET OF ATORVASTATIN USING STATISTICAL DESIGN (JMP SOFTWARE)
More complications and cost of promoting of imaginative drugs are more prominent consideration to the improvement of controlled release (CR) drug delivery systems. Sustained release or controlled release drug delivery system helps to reduced toxicity of drug and more patient compliant drug delivery system.
The aim of this study is to have efficient means of manufacturirng of Gastro retentive floating tablet of Atorvastatin Calcium. Atorvastatin is used in the treatment of hyperlipidaemia. Oral bioavailability of atorvastatin calcium is less than 12% due to instability and in complete absorption. It also undergoes high first pass metabolism. It is absorbed more in the upper part of the GIT. Gastro retentive drug delivery system of Atorvastatin enhanced the bioavailability by retaining the drug in upper part of GIT and by preventing the first pass metabolism of the drug. The objective of present work was to create and assessed oral extended release gastro retentive tablet dosage form of Atorvastatin by using direct compression method using Methocel K4MDC2, Methocel K100MDC2 and Glyceryl behenate using Statistical design (JMP software). Sodium bicarbonate and Citric Acid is used as gas generating agent which helps to float the tablet.
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