FORMULATION AND EVALUATION OF NASAL INSITU GEL OF SUMATRIPTAN SUCCINATE FOR THE TREATMENT OF MIGRAINE
In situ gelling system are better and formulation of time since they have multiple advantages over conventional drug delivery system includes better bioavailability ,retention on the desired site and patient compliance .Nasal drug delivery is a better option to deliver drug across Blood brain barrier and in this research work an attempt was made to prepare insitu temperature triggered nasal gel of Sumatriptan Succinate for the treatment of Migraine .For the preparation of best insitu gel Poloxamer 188 in different concentration was used to formulate insitu gel along with HPMC K4M .The optimized formulation was chosen after evaluating the prepared gel for pH, Viscosity, Gel strength and mucoadhesive strength then final optimized formulation was subjected for texture analysis ,in vitro drug release and Differential Scanning Calorimetery and drug release data was also evaluated for Release kinetic of formulation .Formulation batch F5 was selected as best formulation batch because it exhibited best result among all the prepared formulation and proved as promising temperature triggered formulation of insitu gel.
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