Sense and response in the cell
Almost a century ago, Paul Ehlrich proposed the concept of the ‘receptors’ as sensing components of cellular signaling pathways for the mediation of downstream response in context of toxin action. Since then, we have come a long way in describing the signal transduction through dynamic sense & response in various domains of cell physiology studies, beyond the static ‘receptor-ligand’ mechanism. A multi-nodal characteristic of such signaling modules generates an enriched version of temporal signals responsible for a fine-tuned cellular response based on the identity and severity of stimulus. Here, we review diverse modes of dynamic signal transduction mechanism for efficient cellular response.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeÂ The Effect of Open Access).