Synthesis and Characterisation of Starch Glutamate as a Novel Superdisintegrant
Superdisintegrants have been developed to improve the disintegration process of the fast dissolving tablets. Superdisintegrants acts as structural weakner in fast dissolving tablets and helps in the quick breakup of the tablet into small particles. A new novel superdisintegrant starch glutamate has been synthesized by esterification process and characterized by the FTIR, X-ray diffraction and scanning electron microscopy. Starch glutamate physical and micromeritics properties have been evaluated.The prepared starch glutamate was in soluble in aqueous buffers, organic and in-organic solvents tested. It was free flowing, amorphous in nature, having good swelling index, excellent flow property. The swelling index of starch glutamate was found to be 1200 indicating the suitability of starch glutamate as superdisintegrant in the formulation of fast dissolving dosage forms.
Keywords: Superdisintegrants, Starch glutamate, Swelling index.
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