Callicarpa macrophylla Leaves Extracts Evaluated as Hepatoprotective in Wistar Rats

  • Mohammad Shabib Akhtar Department of Pharmacology, School of Pharmacy, OPJS University, Churu, Rajasthan (India)
  • Anil Kumar Middha Department of Pharmacology, School of Pharmacy, OPJS University, Churu, Rajasthan (India)
  • Vinay Kumar Department of Pharmacology, School of Pharmacy, KIET, Ghaziabad, Uttar Pradesh (India)


Liver is one of the most important organ, which plays a provital role in regulating various physiological processes in the body. It has great capacity to detoxicate toxic substances and synthesize useful principles. Callicarpa macrophylla has witnessed pivotal role in herbal medicine since several years. The ethanolic & aqueous extracts of Callicarpa macrophylla leaves was tested for its phytochemical constituents and hepatoprotective activity against CCl4 induced hepatotoxicity in wistar rats. The results revealed that the oral administration of CCl4 (2 mL/kg) to the animals caused statistically significant (p<0.05) increases in the serum activities of SGOT, SGPT, ALP and bilirubin when compared with control group where there was decreased in level of total protein and albumin. The extract at a dose of200 & 400 mg/kg(for both extract) was able to protect against CCl4 induced hepatotoxicity in albino rat as revealed by significant decreases in the serum level of SGOT, SGPT, ALP and bilirubin and whereas an increase in total protein concentration when compared to the CCl4+distilled water treated group. The ethanolic extract at 400mg/kg, p.o. was found most effective among all the extract treatments when compared to CCl4+distilled water treated groups. The further studies are needed to evaluate potential usefulness of ethanolic and aqueous extract in clinical condition associated with liver damage.

Keywords: Callicarpa macrophylla, CCl4, Hepatotoxicity, Liver enzymes and bilirubin


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Author Biographies

Mohammad Shabib Akhtar, Department of Pharmacology, School of Pharmacy, OPJS University, Churu, Rajasthan (India)

Department of Pharmacology, School of Pharmacy, OPJS University, Churu, Rajasthan (India)

Anil Kumar Middha, Department of Pharmacology, School of Pharmacy, OPJS University, Churu, Rajasthan (India)

Department of Pharmacology, School of Pharmacy, OPJS University, Churu, Rajasthan (India)

Vinay Kumar, Department of Pharmacology, School of Pharmacy, KIET, Ghaziabad, Uttar Pradesh (India)

Department of  Pharmacology, School of Pharmacy, KIET, Ghaziabad, Uttar Pradesh (India)


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Akhtar M, Middha AK, Kumar V. Callicarpa macrophylla Leaves Extracts Evaluated as Hepatoprotective in Wistar Rats. JDDT [Internet]. 15Jun.2019 [cited 6Jul.2020];9(3-s):490-9. Available from: