Formulation Development and Evaluation of Gastroretentive Delivery System (Microspheres) Using Natural Polymer
Abstract
Microspheres are novel drug delivery approach to control release of pharmacologically active ingredient as per patient need. Natural polymers like fenugreek mucilage are cheap, biodegradable and have been proved safe for pharmaceutical formulation. Higher loading efficiency was observed for all the formulations and also the drug release was observed for the period of 12 hours. Thus, the simvastatin microsphere using fenugreek mucilage showed promising results in retarding the drug release. It can be concluded from whole study that due to the formation of polymeric network system or other active moiety can be easily entrapped with the matrix and hydration and swelling of natural polymer controlled their release pattern
Downloads
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.