A Review on Formulation and Evaluation of Sustained Release Tablet of Devilproex Sodium

  • , Kusum
  • Avinash Kumar Gupta
  • Manish Kumar Gupta
  • Vijay Sharma

Abstract

An appropriately designed drug delivery system can be a major step towards solving these two problems. This technique for the drug   administration is termed as ‘sustained release’ or ‘controlled release.  Drugs  with  dosage  not  exceeding  125mg  –  325mg  are  more  suited  as  extended  release  products in order to limit the size of the delivery system.   In  the  case  of  soluble  matrix  the  matrix  swells  or  dissolves.  These matrices then undergo surface erosion with little or no bulk erosion. Divalproex sodium dissociates to the valproate ion in the gastrointestinal tract. The mechanisms by which valproate exerts its therapeutic effects have not been established. One of its most important characteristics is the high gelation velocity and viscosity, which has a significant effect on the release kinetics of the incorporated drug. It was proven that HPMC at high concentration promoted the drug release approaching to a zero-order release kinetic because of its gelation properties


Keywords: HPMC, Divalproex sodium, sustained release and zero-order release kinetic

Downloads

Download data is not yet available.
Statistics
21 Views | 79 Downloads
How to Cite
Kusum, , Gupta, A. K., Gupta, M. K., & Sharma, V. (2019). A Review on Formulation and Evaluation of Sustained Release Tablet of Devilproex Sodium. Journal of Drug Delivery and Therapeutics, 9(4), 660-662. https://doi.org/10.22270/jddt.v9i4.3067

Most read articles by the same author(s)