Niosomes: A Promising Approach in Drug Delivery Systems

  • Aditya Sharma
  • Lakhvinder Kumar
  • Prevesh Kumar
  • Neelkant Prasad
  • Vaibhav Rastogi

Abstract

Design of vesicles as a tool to enhance drug delivery has created a lot of interest among humans operating within drug delivery systems space over the past decade. Niosomes are formations of vesicles by a hydrating mixture of cholesterol and nonionic surfactants. Completely different novel approaches used to deliver these medicines include liposomes, microspheres, engineering science, small emulsions, antibody-loaded drug delivery, magnetic microcapsules, implantable pumps and niosomes. Design and development of novel drug delivery system (NDDS) has two prerequisites. First, it should distribute the drug in accordance with a predetermined rate and second it should release therapeutically effective amount of drug at the site of action. Conventional dosage forms are unable to meet these requisites. Niosomes are basically non-ionic surfactant based vesicles in which an aqueous solution of solute is completely sealed off by a membrane resulting from the group of surfactant macromolecules as bilayer. Niosomes remain in the bloodstream for a reasonable time, which is useful for targeted drug delivery. This review additionally presents an overview of the strategies of preparation of niosome, types of niosomes, characterization and their applications.


Keywords: Niosomes, Vesicles, NDDS, Conventional, Micromolecules.

Downloads

Download data is not yet available.
Statistics
120 Views | 150 Downloads
How to Cite
1.
Sharma A, Kumar L, Kumar P, Prasad N, Rastogi V. Niosomes: A Promising Approach in Drug Delivery Systems. JDDT [Internet]. 15Jul.2019 [cited 23Feb.2020];9(4):635-42. Available from: http://jddtonline.info/index.php/jddt/article/view/3064