Niosomes: A Promising Approach in Drug Delivery Systems

  • Aditya Sharma
  • Lakhvinder Kumar
  • Prevesh Kumar
  • Neelkant Prasad
  • Vaibhav Rastogi

Abstract

Design of vesicles as a tool to enhance drug delivery has created a lot of interest among humans operating within drug delivery systems space over the past decade. Niosomes are formations of vesicles by a hydrating mixture of cholesterol and nonionic surfactants. Completely different novel approaches used to deliver these medicines include liposomes, microspheres, engineering science, small emulsions, antibody-loaded drug delivery, magnetic microcapsules, implantable pumps and niosomes. Design and development of novel drug delivery system (NDDS) has two prerequisites. First, it should distribute the drug in accordance with a predetermined rate and second it should release therapeutically effective amount of drug at the site of action. Conventional dosage forms are unable to meet these requisites. Niosomes are basically non-ionic surfactant based vesicles in which an aqueous solution of solute is completely sealed off by a membrane resulting from the group of surfactant macromolecules as bilayer. Niosomes remain in the bloodstream for a reasonable time, which is useful for targeted drug delivery. This review additionally presents an overview of the strategies of preparation of niosome, types of niosomes, characterization and their applications.


Keywords: Niosomes, Vesicles, NDDS, Conventional, Micromolecules.

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How to Cite
Sharma, A., Kumar, L., Kumar, P., Prasad, N., & Rastogi, V. (2019). Niosomes: A Promising Approach in Drug Delivery Systems. Journal of Drug Delivery and Therapeutics, 9(4), 635-642. https://doi.org/10.22270/jddt.v9i4.3064