Formulation and Evaluation of Chewable Tablets of Pomegranate Peel Extract

  • Mrinalini C. Damle
  • Mangesh R. Bhalekar Department of Pharmaceutical Quality Assurance, All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy Road, Near RTO, Pune-411001.
  • Shivani Rao
  • Mayuri Godse

Abstract

Nowadays, dental caries is one of major oral disease caused due to facultatively anaerobic, gram-positive Streptococcus mutans. Pomegranate peel powder extract is known to have activity against Streptococcusmutans. The ethanolic extract of pomegranate peel powder was tested against streptococcus mutans (MTCC 497t). The Minimum inhibitory concentrations was found to be 6.24 mg/ml. Chewable tablet containing 10х MIC of the pomegranate peel powder was tested by cup plate method for its antibacterial activity against Streptococcus mutans. The study concludes that pomegranate peel extract is a  natural antibacterial source can be used in formulating chewable tablet which are better than chemical formulations specially mouth washes as stay-in-mouth time of these chewable tablet  are extended ensuring good antibacterial activity with good organoleptic properties.


Keywords: Dental caries, Chewable tablet, Pomegranate peel, Streptococcus mutans.

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Author Biographies

Mrinalini C. Damle

Department of Pharmaceutical Quality Assurance, All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy Road, Near RTO, Pune-411001.

Mangesh R. Bhalekar, Department of Pharmaceutical Quality Assurance, All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy Road, Near RTO, Pune-411001.

Department of Pharmaceutical Quality Assurance, All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy Road, Near RTO, Pune-411001.

Shivani Rao

Department of Pharmaceutical Quality Assurance, All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy Road, Near RTO, Pune-411001.

Mayuri Godse

Department of Pharmaceutical Quality Assurance, All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy Road, Near RTO, Pune-411001.

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How to Cite
Damle, M. C., Bhalekar, M. R., Rao, S., & Godse, M. (2019). Formulation and Evaluation of Chewable Tablets of Pomegranate Peel Extract. Journal of Drug Delivery and Therapeutics, 9(4), 318-321. https://doi.org/10.22270/jddt.v9i4.3049