Formulation and Evaluation Transdermal Patch of Hesperidin

  • Rasika A. Bhalerao
  • Mangesh R. Bhalekar
  • Mrinalini C. Damle

Abstract

The aim of the present study is to formulate and evaluate the transdermal patch of  Hesperidin. In the present study, transdermal patch of  Hesperidin were prepared by using HPMC E 5, Eudragit S 100 as a polymer, Dibutyl phthalate as a plasticizer and glycerin as a lubricant. Nine batches (F1-F9) were prepared by solvent evaporation method using methanol and chloroform in ratio 1:1 as a solvent. The prepared transdermal patches were evaluated on the basis of different parameters like weight, thickness, folding endurance, percent moisture content, drug content , in vitro drug release study. To confirm the optimised batch, the data were computed in design expert software. And it was concluded that the prepared formulation F5 batch showed highest percent of drug release.


Keywords: Transdermal drug delivery, Design expert, HPTLC, Hesperidin.

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Author Biographies

Rasika A. Bhalerao

All India Shri Shivaji Memorial Society’s College of Pharmacy, (Affiliated to Savitribai Phule Pune University) Kennedy Road, Near RTO, Pune-411001

Mangesh R. Bhalekar

All India Shri Shivaji Memorial Society’s College of Pharmacy, (Affiliated to Savitribai Phule Pune University) Kennedy Road, Near RTO, Pune-411001

Mrinalini C. Damle

All India Shri Shivaji Memorial Society’s College of Pharmacy, (Affiliated to Savitribai Phule Pune University) Kennedy Road, Near RTO, Pune-411001

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How to Cite
Bhalerao, R. A., Bhalekar, M. R., & Damle, M. C. (2019). Formulation and Evaluation Transdermal Patch of Hesperidin. Journal of Drug Delivery and Therapeutics, 9(4), 311-317. https://doi.org/10.22270/jddt.v9i4.3048