An efficient and facile synthesis of the hybrid scaffold of Pyrazole-Triazole-Chromenes nucleus using PS-TBD as a green catalyst

  • Nileshkumar D. Vala Shree P. M. Patel Institute of Post Graduate Studies & Research in applied Science, Sardar Patel University, Anand-388001, Gujarat, (INDIA)
  • Tapan H. Parekh Shree P. M. Patel Institute of Post Graduate Studies & Research in applied Science, Sardar Patel University, Anand-388001, Gujarat, (INDIA)
  • Mehulsinh R. Chhasatia Shree P. M. Patel Institute of Post Graduate Studies & Research in applied Science, Sardar Patel University, Anand-388001, Gujarat, (INDIA)

Abstract

A series of 16 derivatives of pyrazole-triazole-chromene moieties (4a-p) were synthesized via one-pot cyclocondensation reaction of pyrazole-triazole aldehyde (1a-d), 1, 3 diketone (3a-d) and malononitrile (2a) in presence of PS-TBD as catalyst. The reusability of PS-TBD (polystyrene supported 7-methyl-1, 5, 7-triazabicyclo [4.4.0] dec-5-ene) catalyst makes this reaction quick and efficient. On the basis of various trials and its results, best performance and reusability of catalyst was observed at 5 mol% concentration. The reusability of catalyst founds up to 5 runs. A synthesized compound was characterized by 1HNMR, 13CNMR, FT-IR and C, H, N elemental analysis and confirms theoretical chemical reaction.


Keywords: Chromenes, Pyrazole, Triazole, PS-TBD catalysis Chemistry

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Author Biographies

Nileshkumar D. Vala, Shree P. M. Patel Institute of Post Graduate Studies & Research in applied Science, Sardar Patel University, Anand-388001, Gujarat, (INDIA)

Shree P. M. Patel Institute of Post Graduate Studies & Research in applied Science, Sardar Patel University, Anand-388001, Gujarat, (INDIA)

Tapan H. Parekh, Shree P. M. Patel Institute of Post Graduate Studies & Research in applied Science, Sardar Patel University, Anand-388001, Gujarat, (INDIA)

Shree P. M. Patel Institute of Post Graduate Studies & Research in applied Science, Sardar Patel University, Anand-388001, Gujarat, (INDIA)

Mehulsinh R. Chhasatia, Shree P. M. Patel Institute of Post Graduate Studies & Research in applied Science, Sardar Patel University, Anand-388001, Gujarat, (INDIA)

Shree P. M. Patel Institute of Post Graduate Studies & Research in applied Science, Sardar Patel University, Anand-388001, Gujarat, (INDIA)

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How to Cite
Vala, N. D., Parekh, T. H., & Chhasatia, M. R. (2019). An efficient and facile synthesis of the hybrid scaffold of Pyrazole-Triazole-Chromenes nucleus using PS-TBD as a green catalyst. Journal of Drug Delivery and Therapeutics, 9(4), 222-226. https://doi.org/10.22270/jddt.v9i4.3035