Synthesis and Evaluation of Phenol Derivatives of Sulfonyl Chloride Quinoxaline

  • Rakesh Goyal Research Scholar, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India
  • Mukesh Sharma Research Scholar, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India
  • Dharmendra Ahuja Professor, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India
  • Anurekha Jain Professor, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Abstract

The objective of the present study was to synthesize some new 7-sulfonate of 2, 3- Diphenyl quinoxaline which are more potential as antibacterial than parent quinoxalines. The present study was synthesis of derivatives of sulfonyl chloride quinoxaline and physicochemical and spectral characterization, in vitro antimicrobial screening against gram positive and gram negative bacteria.The concentration of derivatives used as 200 and 400 microgram initially. When 200 µg concentrations was used R6 shows sensitivity towards S. aureus and R6 shows sensitivity towards gram negative E. coli organism. When 400 µg used then R3, R5, and R6 shows sensitivity in case of gram positive organism. And in case of gram negative organism R5, R6 shows sensitivity.Azithromycin is used as Reference drug and a comparative study was done. As compare to reference drug all derivatives shows less sensitivity than S- Standard and R- quinoxaline derivatives.


Keywords: Diphenyl quinoxaline, QSAR, Quinoxaline, Phenol derivatives

Keywords: QSAR, Quinoxaline, Diphenyl quinoxaline

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Author Biographies

Rakesh Goyal, Research Scholar, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Research Scholar, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Mukesh Sharma, Research Scholar, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Research Scholar, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Dharmendra Ahuja, Professor, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Professor, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Anurekha Jain, Professor, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

Professor, Faculty of Pharmaceutical Sciences Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India

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Goyal R, Sharma M, Ahuja D, Jain A. Synthesis and Evaluation of Phenol Derivatives of Sulfonyl Chloride Quinoxaline. JDDT [Internet]. 30Jul.2019 [cited 18Jan.2021];9(4):774-82. Available from: http://jddtonline.info/index.php/jddt/article/view/3016