Phytophospholipid Complexes: A Potential Novel Carrier System for Hepatoprotective Drug Delivery System

Abstract

A variety of huge number of phytoconstituents isolated from the parts of plant or whole plants having the wide spectrum of pharmacological activity. But these phytoconstituents, despite having excellent in vitro bioactivity, but fails to show no in vivo activity  actions, due to their limited lipid or aqueous  solubility, Improper molecular size, improper permeation through biological mucosa or destruction in gastric or  gut environment. So that the potential use of these herbal based drugs are limited due to their poor absorption and poor bioavailability after topical or oral administration. Over the past century, the great advancement has been made for development of novel drug delivery systems (NDDS) of phytoconstituents and herbal extracts such as Nanotechnology based formulation, liposomes, niosomes, transferosomes, ethosomes  Phytophospholipid complex (phytosomes) and microparticle, etc has been developed. Novel potential phytophospholipid complexation methods have been developed by the formulation researcher to enhance the therapeutic activity of plant based drugs. In this method complexation of phytoconstituents with phospholipids in different molar ratio results into the development of novel herbal drug delivery system “phytophospholipid complex”. From the earlier research the formulation scientists have been proved that phytophospholipid complex show better pharmacokinetic and pharmacological profile than conventional herbal extracts. This review article highlights about the phospholipd as a carrier, current and future scenario of phytophospholipid complex and its potential application in hepatoprotection.

Keywords: Herbal Drug Delivery, Phospholipis, Phospholipid Complex, Hepatotoxicity, Hepatoprotection