Aphrodisiac activity of hydro-alcoholic extract of Celosea argentea dried seeds in male rats

  • Nishigandha Yadav Department of pharmacology, AISSMS college of Pharmacy, Savitribai Phule Pune University, Pune, Maharashtra, India
  • Swati Kolhe Department of pharmacology, AISSMS college of Pharmacy, Savitribai Phule Pune University, Pune, Maharashtra, India
  • Sachin Tembhurne Department of pharmacology, AISSMS college of Pharmacy, Savitribai Phule Pune University, Pune, Maharashtra, India

Abstract

Objective: The study was aimed at to investigate the aphrodisiac activity of hydro-alcoholic extract of Celosea argentea dried seeds (Amaranthacea) in male albino rats in different doses. Material and methods: The animals were selected in the present investigation on the basis of their performance in the Copulatory arena and runway apparatus. After selection animal (n=6), they were treated with extract of Celosea argentea (200 and 400 mg/kg) and sildenafil citrate (5mg/kg) orally. While the control animals were given with normal water. All the treatments were given for 21days. Sexual motivation and mating behavior parameters in male rats were monitored on 11th and 21st day of treatment pairing with receptive females. After termination of drug treatment the parameter such as sexual motivation, mating behavior, serum testosterone level, histological examination of testes, relative organ weight and body weight percent were evaluated. Result: The hydro-alcoholic extract of celosia argentea seeds showed a significant increase in mating behavior, serum testosterone levels, testes- body weight ratio as compared to vehicle control, while at the dose of 400mg/kg of Celosea argentea seeds extract assume closer resemblance of above parameters with the standard used. Conclusion: The results of the study strongly suggest that the seed extract of Celosia argentea have good aphrodisiac activity.


Keywords: Aphodisiac, Celosea argentea, sexual motivation, mating behavior, Serum testosterone level

Downloads

Download data is not yet available.

Author Biographies

Nishigandha Yadav, Department of pharmacology, AISSMS college of Pharmacy, Savitribai Phule Pune University, Pune, Maharashtra, India

Department of pharmacology, AISSMS college of Pharmacy, Savitribai Phule Pune University, Pune, Maharashtra, India

Swati Kolhe, Department of pharmacology, AISSMS college of Pharmacy, Savitribai Phule Pune University, Pune, Maharashtra, India

Department of pharmacology, AISSMS college of Pharmacy, Savitribai Phule Pune University, Pune, Maharashtra, India

Sachin Tembhurne, Department of pharmacology, AISSMS college of Pharmacy, Savitribai Phule Pune University, Pune, Maharashtra, India

Department of pharmacology, AISSMS college of Pharmacy, Savitribai Phule Pune University, Pune, Maharashtra, India

References

1. Singh R, Ashraf A, Jeyabalan G, Semwal A, Jaikishan. A overview of the current methodologies used for evaluation of aphrodisiac agent. Journal of Acute Diseas, 2013; 85-91.
2. Ahn TY, et al. Prevalence and risk factors for erectile dysfunction in Korean men: results of an epidemiological study. J Sex Med, 2007; 4(5):1269-1276.
3. Wagner G, Saenzde TI. Clinical review update on male erectile dysfunction. Br Med J, 1998; 316:678-682
4. Park k, Hwang EC, Kim SO. Prevalence and medical management of erectile dysfunction in Asia. Asian J Androl, 2011; 13(4):543-549.
5. Meinhardt W, Kropman RF, Vermeji P. Comparative tolerability and efficacy of treatments of impotence. drug saf, 1999; 20:133-146
6. Arunkumar S, Muthuse vamuth. Analysis of Phytochemical constitutes and antimicrobial activities of Aloevera against clinical pathogens. World J. Agricultural Sci, 2009; 5(5):572-576
7. Indurwade NH, Kawtikar PS, Kosalge SB, Janbandhu NV. Indian Drugs 2005:67
8. Patel DK, Kumar R, Prasad SK, Hemalatha S. Pharmacologically screened aphrodisiac plant- A review of current scientific literature. Asian Pacific Journal of Tropical Biomedicine, 2011; S131-S38.
9. Hara H. The Flora of Eastern Himalaya. Tokyo University Press, Japan, 1966. P.407
10. Ying Tang, Hai-liang Xin, Mei-li Guo. Review on research of the phytochemistry and pharmacological activities of celosea argentea. Revista Brasileira de Farmacognosia, 2016; 26:787-796
11. Kirtikar KR, Basu BD. Indian Medicinal Plants. 2nd ed. Allahabad India: LM Basu Publishers; 1975. P.2508-2509.
12. Agmo Anders. Male rat sexual behavior. Brain Research Protocols, 1997; 1:203-209
13. Singh S, Nair V, Gupta YK. Evaluation of the aphrodisiac activity of Tribulus terrestris Linn. In sexually sluggish male albino rats. Journal of Pharmacology and Pharmacotherapeutics, 2012; 3(1):43-47.
14. Lopez HH, Wurzel G, Ragen B. The effect of acute bupropion on sexual motivation and behavior in the female rat. Pharmacology, Biochemistry and Behavior, 2007; 87:369-379.
15. Kaspate D, et al. To study an Aphrodisiac activity of hydroalcoholic extract of withanea somnifera dried roots in female wistar rats. IJPSR, 2015; 6(7):2820-2836.
16. Lopez HH, Olster HD, Ettenberg A. Sexual motivation in the male rat: The role of primary Incentives and Copulatory experience.Hormones and Behavior, 1999; 36:176-185.
17. Dewsbury DA, Davis HN, JR. Effects of reserpine on the Copulatory behavior of male rats. Physiology and Behavior, 1970; 5: 1331-1333.
18. Sahoo HB, Nandy S, Senapati AK, Sarangi SP, Sah00 SK. Aphrodisiac activity of polyherbal formulation in experimental models on male rats. Pharmacognosy Research, 2014; 6(2):120-126.
19. Zade V, Dabhadkar D. Evaluation of the potential aphrodisiac activity Psoralea corylifolia in male Albino Rats. Asian Journal of Biomedical and Pharmaceutical Sciences, 2013; 3(22):18-27.
20. Sekar suresh, Elumalai Prithiviraj, Seppan Prakash. Dose- and time-depedent effects of ethanolic extract of Mucuna pruriens Linn. Seed on sexual behavior of normal male rats. Journal of Ethanopharmacology, 2009; 122:497-501.
21. Cao JF, Zhang PY, Xu CW, Huang TT, Bal YG, Chen KS, et al. Effect of aqueous extract of arctium lappa L. (burdock) roots on the sexual behavior of male rats. BMC complement altem Med, 2012; 12:1-8
22. Aversa A, Fabbri A. New oral agents for erectile dysfunction:What is changing in our practice? Asian J Androl, 2001; 3:175-179.
23. Gauthaman K, Adaikan PG, Prasad RN. Aphrodisiac propreties of tribulus terrestris extract (potodiascin) in normal and castrated rats. Life sci, 2002; 71:1385-1396.
24. Drewes SE, Gerge J, Khan F. Recent finding on natural products with erectile dysfunction activity. Phytochemistry, 2003; 62: 1019-1025
25. Gauthaman K, Adalkan PG. The hormonal effects of Tribulus terrestis ans its role in the management of male erectile dysfunction-An evaluation using primates, rabbit and rat. Phytomedicine, 2008; 15:44-54.
26. Rathasooriya WD, Femando TS. Effect of black tea brew of camella sinesis on sexual competence of male rats. J Ethanopharmacol, 2008; 118:373-377.
27. Yang NJ, Kaphle K, Wang P, Jang D, Wa L, Lin J, et al. Effect of aqueous extract of ‘Betel Quild’ ans its constituents on testosterone production by dispersed mouse Intestinal cell. Am J Chin Med 2004; 32: 705-715.
28. Murphy LL, Lec T. Ginseng, Sex behavior and nitric oxide. Ann NY Acad Sci, 2002; 962:372-377.
29. Thakur M, Dixit VK. Effect of chlorophytum borivilianum on androgenic sexual behavior of male rats. Indian drugs, 2006; 43:300-306.
Statistics
15 Views | 62 Downloads
How to Cite
Yadav, N., Kolhe, S., & Tembhurne, S. (2019). Aphrodisiac activity of hydro-alcoholic extract of Celosea argentea dried seeds in male rats. Journal of Drug Delivery and Therapeutics, 9(3-s), 296-302. https://doi.org/10.22270/jddt.v9i3-s.3011