Solid Dispersion as Strategy to Improve the Solubility of Poorly Water Soluble Drugs and their Utilization and Consideration during Formulation Development

  • MAHESH BABANRAO SHEJUL Department of quality assurance technique, Pravara Rural College of Pharmacy, Pravaranagar, Tal- Rahuri, Dist- Ahmednagar, India
  • R.K. Godge Department of quality assurance technique, Pravara Rural College of Pharmacy, Pravaranagar, Tal- Rahuri, Dist- Ahmednagar, India
  • S.B. Kakad Department of quality assurance technique, Pravara Rural College of Pharmacy, Pravaranagar, Tal- Rahuri, Dist- Ahmednagar, India
  • S.S. Siddheshwar Department of quality assurance technique, Pravara Rural College of Pharmacy, Pravaranagar, Tal- Rahuri, Dist- Ahmednagar, India

Abstract

Solid dispersions are most promising system to increase the solubility of poorly water soluble drugs.  By using reduction in drug particle size in required specification, and due to that improving drug wettability, bioavailability may be todays need. Solid dispersion generally presented as amorphous products, mainly obtained by two major different methods, melting and solvent evaporation. Now days, surfactants have been included to stabilize the formulations, thus avoiding drug recrystallization and potentiating their solubility. New manufacturing processes to obtain solid dispersions have also been developed to reduce the drawbacks of the initial process. In this review, it is intended to discuss the consideration during formulation development also role of hydrophobic polymer for solubility enhancement various strategy to inhibit the recrystallization.


Keywords: Solid dispersion, recrystallization, solubility, bioavailability, dissolution rate, hydrophobic polymer.

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Author Biographies

MAHESH BABANRAO SHEJUL, Department of quality assurance technique, Pravara Rural College of Pharmacy, Pravaranagar, Tal- Rahuri, Dist- Ahmednagar, India

Department of quality assurance technique, Pravara Rural College of Pharmacy, Pravaranagar, Tal- Rahuri, Dist- Ahmednagar, India 

R.K. Godge, Department of quality assurance technique, Pravara Rural College of Pharmacy, Pravaranagar, Tal- Rahuri, Dist- Ahmednagar, India

Department of quality assurance technique, Pravara Rural College of Pharmacy, Pravaranagar, Tal- Rahuri, Dist- Ahmednagar, India 

S.B. Kakad, Department of quality assurance technique, Pravara Rural College of Pharmacy, Pravaranagar, Tal- Rahuri, Dist- Ahmednagar, India

Department of quality assurance technique, Pravara Rural College of Pharmacy, Pravaranagar, Tal- Rahuri, Dist- Ahmednagar, India 

S.S. Siddheshwar, Department of quality assurance technique, Pravara Rural College of Pharmacy, Pravaranagar, Tal- Rahuri, Dist- Ahmednagar, India

Department of quality assurance technique, Pravara Rural College of Pharmacy, Pravaranagar, Tal- Rahuri, Dist- Ahmednagar, India 

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SHEJUL, M., Godge, R., Kakad, S., & Siddheshwar, S. (2019). Solid Dispersion as Strategy to Improve the Solubility of Poorly Water Soluble Drugs and their Utilization and Consideration during Formulation Development. Journal of Drug Delivery and Therapeutics, 9(3-s), 874-880. https://doi.org/10.22270/jddt.v9i3-s.3007