THE Modified Okra Gum with Silica: A Novel Superdisintegrant for Fast Disintegrating Tablet
The present work on the fast disintegrating tablet of Atenolol was done to formulate a dosage form which can release the active ingredient at the faster rate. The fast disintegrating tablet was made by wet granulation method, the natural gum was used (Modified Okra Gum (Abelmoschus esculentus)). The gum in a modified form is a combination with the silica which increases the disintegration rate of the gum. The swelling index of Modified gum was found as 205. The pH of the gum was found as 6.1, in the gum no microbial growth was found during the study. In the contact with the water, due to high porosity, the tablet mass get swell hence it helps in the faster drug release. The water absorption ratio was found best in F4 formulation that was 84%. The eight formulations were studied for the drug content or the drug release, the drug release of the formulations F1 to F8 was found in the range of 90to 98%. Since the present was done using the natural disintegrating agent, so it was also subjected to study for the efficiency. In the present study the disintegration time of Modified Okra Gum containing tablet was compared with the synthetic disintegrating agent (Sodium Starch Glycolate). Disintegration time of Modified Okra Gum was found best in F4 formulation as 2min 10 sec. whereas tablet containing sodium Starch Glycolate was found as 2 min 34sec.
Keywords: Okra gum, Silica, Super-disintegrant, Modified gum.
2. Alebiowu G, Itiola OA, The Influence of pregelatinized starch disintegrants on interacting variables that acts on disintegrant properties, Journal of Pharmaceutical Technology, 2003; 2(1):28-33.
3. Alexandra A, Tripathi DK, Giri TK, Khan J, Suryawanshi V, Patel RJ, Technology Influencing Rapidly Disintegrating Drug Delivery System, Int. Journal of Pharma Professional Research, 2010; 1:1-10.
4. Antony PJ, Sanghavi NM, A new Disintegrant for Pharmaceutical Dosage form, Journal of Drug Development Industrial Pharmacy, 1997; 23:413-415.
5. Arya A, Chandra A, Fast drug delivery systems: a review, Scholars Research Library, 2010; 2(2):350-361.
6. Avachat A, Ahire VJ, Characterization and evaluation of spray dried co-processed excipients and their application in solid dosage forms, Indian Journal of Pharmacy Science, 2007; 69(1):85-90.
7. Bandari S, Mittapalli RK, Gannu R, Rao YM, Orodispersible tablets: an overview. Asian Journal of Pharmaceutics 2008; 2(1):2-11.
8. Barghouthi ME, Eftaiha A, Rashid I, Al-Remawi M, Badwan A, A novel superdisintegrating agent made from physically modified Chitosan with Silicon dioxide, Informa Health Care, 2008; 34(4): 373-383.
9. Battu SK, Repka MA, Majumdar S, Rao YM, Formulation and evaluation of rapidly disintegrating fenoverine tablets: Effect of superdisintegrants, Journal of Drug Development and Industrial Pharmacy, 2005; 33(11):1225–1232.
10. Baveja SK, Gupta BM, Rheology of Aqueous dispersion of Plantago ovata seed husk - II, Indian Journal of Pharmaceutical Sciences, 1968; 30(11):247-251.
11. Bawuah P, Pierotic MA, Silfsten P, Ervasti T, Ketolainen J, Zeitler JA, Peiponen KE, Detection of porosity of pharmaceutical compacts by terahertz radiation transmission and light reflection measurement techniques. International Journal of Pharmacy, 2014; 4(2):70–76.
12. Belet MH, Derle DV, Analysis of patents pertaining to superdisintegrants used in tablet manufacturing, Journal of intellectual Property Rights, 2008; 13:601-604.
13. Bhowmik D, Chiranjib B, Yadav J, Chandira RM, Sampath KP, Emerging Trends of Disintegrants used in Formulation of Solid Dosage Form. Scholars Research Library, 2010; 2(1): 495-504.
14. Borzacchielo, A, Ambrosias L, Netter P, Nicholais L, Balard A, Sam P, Chitosan-based hydrogels: Synthesis and characterization, European Journal of Pharmaceutics and Biopharmaceutics, 2001; 1(2):861–864.
15. Bussemer T, Peppas NA, Bodmeier R, Evaluation of the swelling, hydration and rupturing properties of the swelling layer of a rupturable pulsatile drug delivery system, European Journal of Pharmaceutics and Biopharmaceutics, 2003; 5(6):261–270.
16. Chadda K, Goldstein S, Byington R, Curb JD, Effects of propranolol after acute MI in patients with congestive heart failure Circulation, European Journal of Pharmacy 1986; 7(3):503-10.
17. Camarco W, Ray D, Druffner A, Selecting superdisintegrant for orally disintegrating tablet formulations, Pharmaceutical Technology Supplement, 2006; 2(1):453-462.
18. Chang RK, Guo X, Burnside B, Couch R, Fast dissolving tablets, Pharm Technol, 2000; 2(4):52-8.
19. Charles R, Laura K, Evaluation of a partially pregelatinized starch in comparison with superdisintegrant in a direct-compression hydrochlorothiazide formulation, American Association of Pharmaceutical Scientists, 1999; 2(1):1-6.
20. Chowdary KP, Hemavathy R, Formulation and dissolution rate studies on dispersible tablets of ibuprofen, Industrial Journal Pharmaceutical Sciences, 2000; 6(3):213-16.
21. Gbenga, A, Oludele AI, Effects of starches on the mechanical properties of paracetamol tablet formulations. II Sorghum and plantain starches as disintegrant, Acta. Pharm, 2003; 5(3):313–320.
22. Goeng AJ, hyung JG, Analysis of Natural Superdisintegrant used in Tablet Manufacturing, International Journal of Green Pharmacy, 2008; 1(3):6-14.
23. Ghosh T, Ghosh A, Prasad D, A review on new generation orodispersible tablets and its future prospective, International Journal of Pharmacy and Pharmaceutical Sciences, 2011; 3(1):1-7.
24. Ishikawa T, Mukai B, Shiraishi S, Utoguchi N, Fuji M, Matsumoto M, Watanabe Y, Preparation of rapidly disintegrating tablet using new types of microcrystalline cellulose (PH-M Series) and low substituted-hydroxypropylcellulose or spherical sugar granules by direct compression method, Chem Pharm Bull, 2001; 49(2):134–139.
25. Iyad R, Mayyas AR, Eftaiha AA, Badwan A, Chitin-silicon dioxide coprecipitate as a novel superdisintegrant, Journal of Pharmaceutical Sciences, 2008; 97(11):4955-69.
26. Jagdale SC, Fernandes NC, Kuchekar BS, Shah TP, Chabukswar AR, Selection of superdisintegrant for Famotidine rapidly disintegrating tablets, European Journal of Pharmaceutics and Biopharmaceutics, 2010; 2(2):65-72.
27. Kazarian SG, Chan KA, Applications of ATR-FTIR spectroscopic imaging to biomedical samples, European Journal of Pharmaceutics and Biopharmaceutics, 2006; 17(7) 858–867.
28. Kim DJ, Angulo Jaramillo R, Vauclin M, Feyen J, Choi SI, Modeling of soil deformation and water flow in a swelling soil, International Journal of Green Pharmacy, 1999; 92(3):217–238.
29. Kin HJ, Lee MN, Water-sorption properties of tablet disintegrant, European Journal of Pharmaceutics and Biopharmaceutics, 1975; 64(3):447–451.
30. Muzzarelli RA, Baldassare V, Conti F, Gazzanelli G, Vasi V, Ferrara P, Biangini G, The biological activity of chitosan: Ultrastructural study, European Journal of Pharmacy 2012; 8(2):247–252.
31. Nachegari SK, Bansal AK, Coprocessed excipients for solid dosage forms, Pharm Technol, 2004; 2(8):52-64.
32. Natalie MC, Stability studies in overview of ICH Guidelines for Drug Products. Matrix Pharmaceutical Inc, 2013; 2(1):321-31.
33. Nunthanid J, Puttipipatkhachorn S, Yamamoto K, Peck GE, Physical properties and molecular behavior of chitosan films, Journal of Drug Development Industrial Pharmacy, 2001; 2(7):143–157.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).