THE Modified Okra Gum with Silica: A Novel Superdisintegrant for Fast Disintegrating Tablet
The present work on the fast disintegrating tablet of Atenolol was done to formulate a dosage form which can release the active ingredient at the faster rate. The fast disintegrating tablet was made by wet granulation method, the natural gum was used (Modified Okra Gum (Abelmoschus esculentus)). The gum in a modified form is a combination with the silica which increases the disintegration rate of the gum. The swelling index of Modified gum was found as 205. The pH of the gum was found as 6.1, in the gum no microbial growth was found during the study. In the contact with the water, due to high porosity, the tablet mass get swell hence it helps in the faster drug release. The water absorption ratio was found best in F4 formulation that was 84%. The eight formulations were studied for the drug content or the drug release, the drug release of the formulations F1 to F8 was found in the range of 90to 98%. Since the present was done using the natural disintegrating agent, so it was also subjected to study for the efficiency. In the present study the disintegration time of Modified Okra Gum containing tablet was compared with the synthetic disintegrating agent (Sodium Starch Glycolate). Disintegration time of Modified Okra Gum was found best in F4 formulation as 2min 10 sec. whereas tablet containing sodium Starch Glycolate was found as 2 min 34sec.
Keywords: Okra gum, Silica, Super-disintegrant, Modified gum.
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