THE Formulation and Characterization of Transdermal Patch of Candesartan Celexitil

  • Shabnam Hira Department of Pharmaceutics, Shivalik College of Pharmacy Nangal, Punjab, India
  • Jagdeep Singh Dua Department of Pharmaceutics, Shivalik College of Pharmacy Nangal, Punjab, India
  • D.N. Prasad Department of Chemistry, Shivalik College of Pharmacy Nangal, Punjab, India
  • Anchal Puri Department of Pharmaceutics, Shivalik College of Pharmacy Nangal, Punjab, India
  • Sahil Kaushal Department of Pharmaceutics, Shivalik College of Pharmacy Nangal, Punjab, India

Abstract

The aim of the present study is to formulate and characterized the transdermal patch of Candesartan celexitil. The objective is study was to increase the bioavailability of drug. In the present study, transdermal patch of Candesartan celexitil were prepared  by solvent casting technique employing HPMC cps 50 polymer and glycerin as plasticizer using mercury as substrate. Total thirteen formulation (F1-F13) were prepared having drug and polymer ratio (1:2, 1:4, 1:6, 1:8, and 1:10). From the selected batch F2 containing drug polymer ratio (1:4), four formulations each were prepared and evaluated containg drug urea (1-4%) and oleic acid (1-4%) as permeation enhancer. The prepared transdermal patches were evaluated on the basis of different parameters like weigh, thickness, folding endurance, percent moisture absorption, percent moisture loss, drug content uniformity, in vitro skin permeation study. The fabricated final transdermal patches were further subjected to in vitro permeation study. In order to confirm the exact mechanism of drug release from all the patches, the data were computed and graphed according to Korsmeyer equation. Diffusion exponent of release process controlled by Super case Ⅱ transport Non- Fickian diffusion, n values of Korsmeyer- Peppas model shows a combination of diffusion and dissolution mechanism indicating the drug release from the formulation was controlled by more than one process. It was concluded that the prepared formulation F13 (4% w/v of oleic acid) showed highest cumulative percent drug release and increase the bioavailability of the drug.


Keywords: Novel drug delivery system, Transdermal drug delivery, Transdermal drug delivery system, Differential scanning calorimetry.

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Author Biographies

Shabnam Hira, Department of Pharmaceutics, Shivalik College of Pharmacy Nangal, Punjab, India

Department of Pharmaceutics, Shivalik College of Pharmacy Nangal, Punjab, India

Jagdeep Singh Dua, Department of Pharmaceutics, Shivalik College of Pharmacy Nangal, Punjab, India

Department of Pharmaceutics, Shivalik College of Pharmacy Nangal, Punjab, India

D.N. Prasad, Department of Chemistry, Shivalik College of Pharmacy Nangal, Punjab, India

Department of Chemistry, Shivalik College of Pharmacy Nangal, Punjab, India

Anchal Puri, Department of Pharmaceutics, Shivalik College of Pharmacy Nangal, Punjab, India

Department of Pharmaceutics, Shivalik College of Pharmacy Nangal, Punjab, India

Sahil Kaushal, Department of Pharmaceutics, Shivalik College of Pharmacy Nangal, Punjab, India

Department of Pharmaceutics, Shivalik College of Pharmacy Nangal, Punjab, India

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How to Cite
Hira, S., Dua, J. S., Prasad, D., Puri, A., & Kaushal, S. (2019). THE Formulation and Characterization of Transdermal Patch of Candesartan Celexitil. Journal of Drug Delivery and Therapeutics, 9(3-s), 255-262. https://doi.org/10.22270/jddt.v9i3-s.3001

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