NASAL DRUG DELIVERY: SUCCESS THROUGH INTEGRATED DEVICE DEVELOPMENT
AbstractTransmucosal nasal delivery is a promising drug delivery option where common drug administrations (e.g., intravenous, intramuscular, or oral) are inapplicable. Recently, it has been shown that many drugs have better bioavailability by nasal route than by oral route. This has been attributed to rich vasculature and a highly permeable structure of the nasal mucosa coupled with avoidance of hepatic first-pass elimination, gut wall metabolism and/or destruction in the gastrointestinal tract. The physiology of the nose presents obstacles, but offers a promising route for non-invasive systemic delivery of numerous therapies and debatably drug delivery route to the brain.Â Intranasal microemulsions, gels and microspheres have gained increased interest in recent years as a delivery system for protein and peptides through nasal route. Since building a more efficient nasal drug delivery device requires not only better device design butÂ a far more versatile technology platform; one that delivers optimal nasal deposition, with formulation flexibility to work successfully with the many variables of the formulation itself. Thus present review focuses on innovations in nasal drug delivery devices.
Download data is not yet available.
125 Views | 162 Downloads
How to Cite
Dhakar R. NASAL DRUG DELIVERY: SUCCESS THROUGH INTEGRATED DEVICE DEVELOPMENT. JDDT [Internet]. 25Oct.2011 [cited 3Jun.2020];1(1). Available from: http://jddtonline.info/index.php/jddt/article/view/3
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).