Syntheses and Pharmacological Activities of Isatin Derivatives

  • Mayank Yadav
  • Neetu Sachan
  • Sushil Kumar
  • Asif Husain

Abstract

Twenty derivatives of isatin (1H-indole-2, 3-Dione) were synthesized by the schematic route as per as scheme. These were further characterized by spectroscopic analysis. All the novel synthesized derivatives of isatin were screened for their antimicrobial activity against Gram-positive bacteria: Staphylococcus aureus, Bacillus subtilis, Streptococcus pneumonia; Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and fungal strains: Candida albicans, Aspergillus niger, Penicillium chrysogenum, Rhizopus oryzae by cup-plate method. Results of antimicrobial screening showed that compound ID5, ID9, ID15 and ID18 possess potent antibacterial activity. Whereas ID1, ID3, ID4, ID7 and ID20 possess antifungal activity comparable to standard drugs.


Keywords: Isatin; Antimicrobial; Antibacterial; Antifungal.

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Yadav, M., Sachan, N., Kumar, S., & Husain, A. (2019). Syntheses and Pharmacological Activities of Isatin Derivatives. Journal of Drug Delivery and Therapeutics, 9(3-s), 744-748. https://doi.org/10.22270/jddt.v9i3-s.2986