Evaluation of Antidiabetic Activity of Ethanolic Extract of Ajuga Parviflora in Diabetic Rats

  • Rupa Kumari Department of Pharmaceutical Chemistry, Azad Institute of Pharmacy and Research, Lucknow (Affiliated to Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India).
  • , Amit Department of Pharmaceutical Chemistry, Azad Institute of Pharmacy and Research, Lucknow (Affiliated to Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India).
  • Pawan Kumar Department of Pharmaceutical Chemistry, Azad Institute of Pharmacy and Research, Lucknow (Affiliated to Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India).
  • Rizwan Ahmed Department of Pharmaceutical Chemistry, Azad Institute of Pharmacy and Research, Lucknow (Affiliated to Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India).

Abstract

The aim of the study was to evaluate the antidiabetic activity of ethanolic extract of whole plant of Ajuga  parviflora  in diabetic induced Sprague Dawley rats. Acute toxicity study was done on screened rats for 14 days. The rats were divided into four groups like normal, diabetic, treated and standard (diabetes treated with Glibenclamide). Streptozocin 160mg /kg body weight was administered intra peritoneally to rat for the induction of diabetes. After the confirmation of diabetes, the rats were subjected to further in-vivo studies. The formulation obtained by ethanolic extract of whole plant of Ajuga parviflora  (60mg/kg) were administered orally to diabetic rats for 28 days. The body weight and fasted blood glucose level measured in diabetic and non-diabetic rats at the end  of experiments. The formulation shows significant reduction in blood glucose level in Streptozocin induced rats that is comparable to Glibenclamide.. Methanolic extract of medicinal herb Ajuga  parviflora  Benth. was evaluated for phytochemical screening the plant extract showed the presence of aromatic compounds, carbohydrates and others.


Keywords: Ajuga parviflora, Sprague Dawley rat, Streptozocin , Phytochemical screnning.

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Author Biographies

Rupa Kumari, Department of Pharmaceutical Chemistry, Azad Institute of Pharmacy and Research, Lucknow (Affiliated to Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India).

Department of Pharmaceutical Chemistry, Azad Institute of Pharmacy and Research, Lucknow (Affiliated to Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India).

, Amit, Department of Pharmaceutical Chemistry, Azad Institute of Pharmacy and Research, Lucknow (Affiliated to Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India).

Department of Pharmaceutical Chemistry, Azad Institute of Pharmacy and Research, Lucknow (Affiliated to Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India).

Pawan Kumar, Department of Pharmaceutical Chemistry, Azad Institute of Pharmacy and Research, Lucknow (Affiliated to Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India).

Department of Pharmaceutical Chemistry, Azad Institute of Pharmacy and Research, Lucknow (Affiliated to Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India).

Rizwan Ahmed, Department of Pharmaceutical Chemistry, Azad Institute of Pharmacy and Research, Lucknow (Affiliated to Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India).

Department of Pharmaceutical Chemistry, Azad Institute of Pharmacy and Research, Lucknow (Affiliated to Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India).

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How to Cite
Kumari, R., Amit, , Kumar, P., & Ahmed, R. (2019). Evaluation of Antidiabetic Activity of Ethanolic Extract of Ajuga Parviflora in Diabetic Rats. Journal of Drug Delivery and Therapeutics, 9(4), 112-115. https://doi.org/10.22270/jddt.v9i4.2984