In-Vitro Evaluation of Drug Release and Antioxidant Activity of Aloe Loaded Chitosan Nanoparticles

  • Shivangi Kesharwani Oriental College of Pharmacy and Research, Oriental University, Indore, India
  • Durgesh Kumari Gupta Oriental College of Pharmacy and Research, Oriental University, Indore, India
  • Mahesh Kumar Gupta Oriental College of Pharmacy and Research, Oriental University, Indore, India

Abstract

Antioxidants play significant responsibility during the treatment of cancer and it’s adverse effects, because in the treatment of cancer by using chemotherapy, free radicals are generated and these free radicals accumulated in the body and cause damage, side effect (such as neurodegenerated disease, atherosclerosis, depression, leukemia, skin disease, diabetes etc.) and even death due to the biological consequence. So, antioxidant inhibits the generation of new and destroys previously present free radicals. A recent study was aimed for novel approach of herbal nanoparticles to get improved efficacy of the drug with fewer side effects. In-vitro Evaluation of Drug Release and Antioxidant Activity of Aloe Loaded Chitosan Nanoparticles were includes in this research. Aloe has good antioxidant property, but in the form of nanoparticles formed with the help of chitosan polymer, it’s enhancing their stability, in-vitro release property. Chitosan is one of the best polymer for nanomedicine formulation because of their low toxicity and high compatibility. Six formulations of aloe loaded chitosan nanopaticles were prepared and evaluated as antioxidant study, in-vitro release and stability studies. Results have shown that the F6 was most stable, good release and high antioxidant property. So, it found that F6 was good formulation among all batches and these nanoparticles can be used as antioxidant agent during the treatment of cancer along with chemotherapeutic drugs for improve their effectiveness and reduce adverse effects.


Keywords: Cancer, Chemotherapy, Herbal, Chitosan nanoparticles, Antioxidant.

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Author Biographies

Shivangi Kesharwani, Oriental College of Pharmacy and Research, Oriental University, Indore, India

Oriental College of Pharmacy and Research, Oriental University, Indore, India

Durgesh Kumari Gupta, Oriental College of Pharmacy and Research, Oriental University, Indore, India

Oriental College of Pharmacy and Research, Oriental University, Indore, India

Mahesh Kumar Gupta, Oriental College of Pharmacy and Research, Oriental University, Indore, India

Oriental College of Pharmacy and Research, Oriental University, Indore, India

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How to Cite
Kesharwani, S., Gupta, D. K., & Gupta, M. K. (2019). In-Vitro Evaluation of Drug Release and Antioxidant Activity of Aloe Loaded Chitosan Nanoparticles. Journal of Drug Delivery and Therapeutics, 9(4), 43-52. https://doi.org/10.22270/jddt.v9i4.2979